R
Rami I. Aqeilan
Researcher at Hebrew University of Jerusalem
Publications - 152
Citations - 14107
Rami I. Aqeilan is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: WWOX & WW domain. The author has an hindex of 51, co-authored 144 publications receiving 13034 citations. Previous affiliations of Rami I. Aqeilan include Thomas Jefferson University & Ohio State University.
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Journal ArticleDOI
miR-15 and miR-16 induce apoptosis by targeting BCL2.
Amelia Cimmino,George A. Calin,Muller Fabbri,Marilena V. Iorio,Manuela Ferracin,Masayoshi Shimizu,Sylwia E. Wojcik,Rami I. Aqeilan,Simona Zupo,Mariella Dono,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Massimo Negrini,Carlo M. Croce +17 more
TL;DR: It is demonstrated thatmiR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate BCL2 at a posttranscriptional level and are natural antisense B cl2 interactors that could be used for therapy of Bcl1-overexpressing tumors.
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MiR-15a and miR-16-1 cluster functions in human leukemia.
George A. Calin,Amelia Cimmino,Muller Fabbri,Manuela Ferracin,Sylwia E. Wojcik,Masayoshi Shimizu,Cristian Taccioli,Nicola Zanesi,Ramiro Garzon,Rami I. Aqeilan,Hansjuerg Alder,Stefano Volinia,Laura Z. Rassenti,Xiuping Liu,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +17 more
TL;DR: A high-throughput profiling of genes modulated by miR-15a/16-1 in a leukemic cell line model (MEG-01) and in primary CLL samples is produced and a significant enrichment in cancer genes that directly or indirectly affect apoptosis and cell cycle was found.
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miR-15a and miR-16-1 in cancer: discovery, function and future perspectives
TL;DR: The discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL, are summarized.
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MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis
Flavia Pichiorri,Sung Suk Suh,Marco Ladetto,Michael Kuehl,Tiziana Palumbo,Daniela Drandi,Cristian Taccioli,Nicola Zanesi,Hansjuerg Alder,John P. Hagan,Reinhold Munker,Stefano Volinia,Mario Boccadoro,Ramiro Garzon,Antonio Palumbo,Rami I. Aqeilan,Rami I. Aqeilan,Carlo M. Croce +17 more
TL;DR: A MM miRNA signature is described, which includes miRNAs that modulate the expression of proteins critical to myeloma pathogenesis that were shown to down regulate expression of SOCS-1 and miR-19a and 19b.
Journal ArticleDOI
Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation
Zhaoyong Li,Mohammad Q. Hassan,Mohammed Jafferji,Rami I. Aqeilan,Ramiro Garzon,Carlo M. Croce,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +9 more
TL;DR: It is proposed that this mechanism prevents fibrosis and facilitates mineral deposition when miR-29b reaches peak levels and is a key regulator of development of the osteoblast phenotype by targeting anti-osteogenic factors and modulating bone extracellular matrix proteins.