Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation
Zhaoyong Li,Mohammad Q. Hassan,Mohammed Jafferji,Rami I. Aqeilan,Ramiro Garzon,Carlo M. Croce,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +9 more
Reads0
Chats0
TLDR
It is proposed that this mechanism prevents fibrosis and facilitates mineral deposition when miR-29b reaches peak levels and is a key regulator of development of the osteoblast phenotype by targeting anti-osteogenic factors and modulating bone extracellular matrix proteins.About:
This article is published in Journal of Biological Chemistry.The article was published on 2009-06-05 and is currently open access. It has received 551 citations till now. The article focuses on the topics: Osteoblast & Cellular differentiation.read more
Citations
More filters
Journal ArticleDOI
Targeting microRNAs in cancer: rationale, strategies and challenges.
TL;DR: The role of miRNAAs in tumorigenesis is described and the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer are critically discussed.
Journal ArticleDOI
MicroRNA control of bone formation and homeostasis
Jane B. Lian,Gary S. Stein,Andre J. van Wijnen,Janet L. Stein,Mohammad Q. Hassan,Tripti Gaur,Ying Zhang +6 more
TL;DR: Characterization of miRNAs that operate through tissue-specific transcription factors in osteoblast and osteoclast lineage cells, as well as intricate feedforward and reverse loops, has provided novel insights into the supervision of signaling pathways and regulatory networks controlling normal bone formation and turnover.
Journal ArticleDOI
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
Brian N. Chorley,Michelle R. Campbell,Xuting Wang,Mehmet Karaca,Deepa Sambandan,Fatu Bangura,Peng Xue,Jingbo Pi,Steven R. Kleeberger,Douglas A. Bell +9 more
TL;DR: Validation of selected candidate genes using parallel ChIP techniques and in NRF2-silenced cell lines indicated that the expression of about two-thirds of the candidates are likely to be directly NRF1-dependent including retinoid X receptor alpha (RXRA), which has implications for response to retinoids treatments and adipogenesis.
Journal ArticleDOI
miR-214 targets ATF4 to inhibit bone formation
Xiaogang Wang,Baosheng Guo,Baosheng Guo,Qi Li,Jiang Peng,Zhijun Yang,Aiyuan Wang,Dong Li,Zhibo Hou,Ke Lv,Guanghan Kan,Hongqing Cao,Heng Wu,Heng Wu,Jinping Song,Xiaohua Pan,Qiao Sun,Shukuan Ling,Yuheng Li,Mu Zhu,Pengfei Zhang,Songlin Peng,Xiaoqing Xie,Tao Tang,An Hong,Zhaoxiang Bian,Yanqiang Bai,Aiping Lu,Yinghui Li,Fuchu He,Ge Zhang,Ge Zhang,Yingxian Li +32 more
TL;DR: Elevated miR-214 levels correlated with a lower degree of bone formation in bone specimens from aged patients with fractures, and in vitro osteoblast activity and matrix mineralization were promoted by antagomir-214 and decreased by agomIR-214, and mi R-214 directly targeted ATF4 to inhibit osteoblasts activity.
Journal ArticleDOI
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
Tilde Eskildsen,Hanna Taipaleenmäki,Jan Stenvang,Basem M. Abdallah,Nicholas Ditzel,Anne Yaël Nossent,Mads Bak,Sakari Kauppinen,Moustapha Kassem +8 more
TL;DR: It is shown that miRNA-138 (miR-138) modulates osteogenic differentiation of hMSCs and attenuates bone formation in vivo, at least in part by inhibiting the focal adhesion kinase signaling pathway.
References
More filters
Journal ArticleDOI
The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
Journal ArticleDOI
MicroRNAs: small RNAs with a big role in gene regulation
Lin He,Gregory J. Hannon +1 more
TL;DR: Two founding members of the microRNA family were originally identified in Caenorhabditis elegans as genes that were required for the timed regulation of developmental events and indicate the existence of multiple RISCs that carry out related but specific biological functions.
Journal ArticleDOI
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
TL;DR: This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of micro RNA function.
Journal ArticleDOI
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lee P. Lim,Nelson C. Lau,Philip W. Garrett-engele,Andrew Grimson,Janell M. Schelter,John C. Castle,David P. Bartel,Peter S. Linsley,Jason M. Johnson +8 more
TL;DR: These results suggest that metazoan miRNAs can reduce the levels of many of their target transcripts, not just the amount of protein deriving from these transcripts, and seem to downregulate a far greater number of targets than previously appreciated.
Journal ArticleDOI
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
TL;DR: Cloned cDNA encoding Osf2/Cbfa1 is identified as an osteoblast-specific transcription factor and as a regulator of osteoblasts differentiation.