Rebecca A Mancusi

TL;DR: In this paper , the clinical experience from the first four patients with H3K27M-mutated diffuse midline glioma (DIPG) or spinal cord DMG treated with GD2-CAR T cells at dose level 1 (1 × 106 GD2 CAR T cells per kg administered intravenously).

TL;DR: In this paper , the clinical experience from the first four patients with H3K27M-mutated diffuse midline glioma (DIPG) or spinal cord DMG treated with GD2-CAR T cells at dose level 1 (1 × 106 GD2 CAR T cells per kg administered intravenously).

TL;DR: The authors explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans following mild respiratory COVID in mice.

TL;DR: In this article , the authors combined radiotherapy with the "don't-eat-me" cell-surface molecule CD47 in small cell lung cancer (SCLC), a highly metastatic form of lung cancer.

TL;DR: Hedgehog (Hh) precursor proteins contain an autoprocessing domain called HhC whose native function is protein cleavage and C-terminal glycine sterylation, which, coupled with efficient kinetics and substrate tolerance, may ease access and open new applications for these suprabiological chimeras.