L
Li Jiang
Researcher at Dana Corporation
Publications - 22
Citations - 559
Li Jiang is an academic researcher from Dana Corporation. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 3 publications receiving 35 citations. Previous affiliations of Li Jiang include Broad Institute.
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Journal ArticleDOI
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
Robbie G. Majzner,Sneha Ramakrishna,Kristen W. Yeom,Shabnum Patel,Harshini Chinnasamy,Liora M. Schultz,Rebecca Richards,Li Jiang,Valentin Barsan,Rebecca A Mancusi,Anna Geraghty,Zina Good,Aaron Mochizuki,Shawn M. Gillespie,Angus Toland,Jasia Mahdi,Agnes Reschke,Esther H Nie,Isabelle J. Chau,Maria Caterina Rotiroti,Christopher Mount,Christina Baggott,Sharon Mavroukakis,Emily Egeler,Jennifer Moon,Courtney Erickson,Sean Green,Michael Kunicki,Michelle Fujimoto,Zach Ehlinger,Warren D. Reynolds,Sreevidya Kurra,Katherine E. Warren,Snehit Prabhu,Hannes Vogel,Lindsey Rasmussen,Timothy T. Cornell,Sonia Partap,Paul B. Fisher,Cynthia J. Campen,Mariella G. Filbin,Gerald A. Grant,Bita Sahaf,Kara L. Davis,Steven R. Feldman,Crystal L. Mackall,Michelle Monje +46 more
TL;DR: In this paper , the clinical experience from the first four patients with H3K27M-mutated diffuse midline glioma (DIPG) or spinal cord DMG treated with GD2-CAR T cells at dose level 1 (1 × 106 GD2 CAR T cells per kg administered intravenously).
Journal ArticleDOI
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
Robbie G. Majzner,Sneha Ramakrishna,Kristen W. Yeom,Shabnum Patel,Harshini Chinnasamy,Liora M. Schultz,Rebecca Richards,Li Jiang,Valentin Barsan,Rebecca A Mancusi,Anna Geraghty,Zina Good,Aaron Mochizuki,Shawn M. Gillespie,Angus Toland,Jasia Mahdi,Agnes Reschke,Esther H Nie,Isabelle J. Chau,Maria Caterina Rotiroti,Christopher Mount,Christina Baggott,Sharon Mavroukakis,Emily Egeler,Jennifer Moon,Courtney Erickson,Sean Green,Michael Kunicki,Michelle Fujimoto,Zach Ehlinger,Warren D. Reynolds,Sreevidya Kurra,Katherine E. Warren,Snehit Prabhu,Hannes Vogel,Lindsey Rasmussen,Timothy T. Cornell,Sonia Partap,Paul B. Fisher,Cynthia J. Campen,Mariella G. Filbin,Gerald A. Grant,Bita Sahaf,Kara L. Davis,Steven A. Feldman,Crystal L. Mackall,Michelle Monje +46 more
TL;DR: In this paper , the clinical experience from the first four patients with H3K27M-mutated diffuse midline glioma (DIPG) or spinal cord DMG treated with GD2-CAR T cells at dose level 1 (1 × 106 GD2 CAR T cells per kg administered intravenously).
Journal ArticleDOI
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma.
Johannes Gojo,Johannes Gojo,Bernhard Englinger,Bernhard Englinger,Li Jiang,Li Jiang,Jens Martin Hübner,McKenzie Shaw,McKenzie Shaw,Olivia A Hack,Olivia A Hack,Sibylle Madlener,Dominik Kirchhofer,Ilon Liu,Ilon Liu,Jason Pyrdol,Volker Hovestadt,Volker Hovestadt,Emanuele Mazzola,Nathan Mathewson,Maria Trissal,Maria Trissal,Daniela Lötsch,Christian Dorfer,Christine Haberler,Angela Halfmann,Lisa Mayr,Andreas Peyrl,René Geyeregger,Benjamin Schwalm,Monica Mauermann,Kristian W. Pajtler,Kristian W. Pajtler,Till Milde,Marni E. Shore,Marni E. Shore,Jack Geduldig,Kristine Pelton,Thomas Czech,Orr Ashenberg,Kai W. Wucherpfennig,Orit Rozenblatt-Rosen,Sanda Alexandrescu,Keith L. Ligon,Keith L. Ligon,Keith L. Ligon,Stefan M. Pfister,Stefan M. Pfister,Aviv Regev,Aviv Regev,Irene Slavc,Walter Berger,Mario L. Suvà,Mario L. Suvà,Marcel Kool,Mariella G. Filbin,Mariella G. Filbin +56 more
TL;DR: Single-cell RNA sequencing is applied to analyze ependymomas across molecular groups and anatomic locations to investigate their intratumoral heterogeneity and developmental origins, revealing a developmental hierarchy underlying ependylomas relevant to biological and clinical behavior.
Journal ArticleDOI
Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas.
Pooja Panwalkar,Benita Tamrazi,Derek Dang,Chan Chung,Stefan Sweha,Siva Kumar Natarajan,Matthew Pun,Jill Bayliss,Martin P. Ogrodzinski,Drew Pratt,Brendan Mullan,Debra Hawes,Fusheng Yang,Chao Lu,Benjamin R. Sabari,Abhinav Achreja,Jin Heon,Olamide Animasahun,Marcin Cieslik,Christopher Dunham,Stephen Yip,Juliette Hukin,Joanna J. Phillips,Miriam Bornhorst,Andrea Griesinger,Andrea Griesinger,Andrew M. Donson,Andrew M. Donson,Nicholas K. Foreman,Nicholas K. Foreman,Hugh J. L. Garton,Jason Heth,Karin M. Muraszko,Javad Nazarian,Javad Nazarian,Carl Koschmann,Li Jiang,Mariella G. Filbin,Deepak Nagrath,Marcel Kool,Andrey Korshunov,Stefan M. Pfister,Stefan M. Pfister,Richard J. Gilbertson,C. David Allis,Arul M. Chinnaiyan,Sophia Y. Lunt,Stefan Bluml,Alexander R. Judkins,Sriram Venneti +49 more
TL;DR: In this article, the oncohistone-like protein E (EHP) was found to be useful in the treatment of childhood posterior fossa group A ependymomas.
Journal ArticleDOI
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
Ilon Liu,Li Jiang,Erik R Samuelsson,Sergio Marco Salas,Alexander M. Beck,Olivia A Hack,Dae Hune Jeong,McKenzie Shaw,Bernhard Englinger,Jenna LaBelle,Hafsa M Mire,Sibylle Madlener,Lisa Mayr,Michael Quezada,Maria Trissal,Eshini Panditharatna,Kati Ernst,Jayne Vogelzang,Taylor A. Gatesman,Matthew E Halbert,Hana Pálová,Petra Pokorná,Jaroslav Sterba,Ondrej Slaby,René Geyeregger,Aaron Diaz,Izac J. Findlay,Matthew D. Dun,Adam C. Resnick,Mario L. Suvà,David T. Jones,Sameer Agnihotri,Jessica Svedlund,Carl Koschmann,Christine Haberler,Thomas Czech,Irene Slavc,Jennifer A. Cotter,Keith L. Ligon,Sanda Alexandrescu,W. K. Alfred Yung,Isabel Arrillaga-Romany,Johannes Gojo,Michelle Monje,Mats Nilsson,Mariella G. Filbin +45 more
TL;DR: In this paper , the authors dissected the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, delineating how age and anatomical location shape glioma cell-intrinsic and -extrinsics features in light of the shared driver mutation.