Renee Duijvelshoff

TL;DR: A fibrous valvular scaffold is designed, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix and offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures.

TL;DR: A fast-degrading biodegradable supramolecular scaffold for arterial applications was designed and evaluated in vivo, suggesting that neo-tissue formation was still in progress, while the host response became quiescent, favoring a regenerative tissue outcome.

TL;DR: In vitro study demonstrates that vascular scaffolds, electrospun from sequence-controlled supramolecular materials with varying ester contents, not only display different susceptibilities to degradation, but also degrade via different mechanisms.

TL;DR: It remains extremely difficult to anticipate graft development and performance in vivo, so a thorough understanding of the mechanobiological mechanisms governing scaffold-driven arterial regeneration as well as potential influences of surgical procedures is warranted to further optimize scaffold designs.

TL;DR: In this paper, a bioresorbable electrospun polymer graft that can be implanted inside a small-diameter vessel was used to support the vessel wall, facilitate cellular infiltration, and guide organized tissue formation.