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Sylvia Dekker
Researcher at Eindhoven University of Technology
Publications - 11
Citations - 314
Sylvia Dekker is an academic researcher from Eindhoven University of Technology. The author has contributed to research in topics: Heart valve & Internal medicine. The author has an hindex of 5, co-authored 9 publications receiving 199 citations.
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Journal ArticleDOI
In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep.
Jolanda Kluin,Hanna Talacua,Anthal I.P.M. Smits,Maximilian Y. Emmert,Marieke Brugmans,Emanuela S. Fioretta,Petra E. Dijkman,Serge H. M. Söntjens,Renee Duijvelshoff,Sylvia Dekker,Marloes W J T Janssen-van den Broek,Valentina Lintas,Aryan Vink,Simon P. Hoerstrup,Simon P. Hoerstrup,Henk M. Janssen,Patricia Y. W. Dankers,Frank P. T. Baaijens,Carlijn V. C. Bouten +18 more
TL;DR: A fibrous valvular scaffold is designed, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix and offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures.
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In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.
M. Uiterwijk,Anthal I.P.M. Smits,Daphne van Geemen,Bas R van Klarenbosch,Sylvia Dekker,Maarten J. Cramer,Jan Willem van Rijswijk,Emily B. Lurier,Emily B. Lurier,Andrea Di Luca,Marieke Brugmans,Tristan Mes,Anton W. Bosman,Elena Aikawa,Paul F. Gründeman,Carlijn V. C. Bouten,J. Kluin,J. Kluin +17 more
TL;DR: The authors showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep.
Journal ArticleDOI
Sheep-specific immunohistochemical panel for the evaluation of regenerative and inflammatory processes in tissue-engineered heart valves
Sylvia Dekker,Daphne van Geemen,Antoon J. van den Bogaerdt,Anita Anita Driessen-Mol,Elena Aikawa,Anthal I.P.M. Smits +5 more
TL;DR: A comprehensive sheep-specific panel of antibodies could serve as a tool to study the spatiotemporal expression of proteins in remodeling tissue-engineered heart valves after implantation in a sheep model, thereby contributing to the understanding of the in vivo processes which ultimately determine long-term success or failure of tissue- engineered heart valves.
Journal ArticleDOI
Intrinsic Cell Stress is Independent of Organization in Engineered Cell Sheets
Inge A. E. W. van Loosdregt,Sylvia Dekker,Patrick W. Alford,Cees W. J. Oomens,S Sandra Loerakker,Carlijn V. C. Bouten +5 more
TL;DR: Investigating whether differences in organization affect the magnitude of intrinsic stress generated by individual myofibroblasts, a frequently used cell source for in vitro engineered heart valves, results indicate that the intrinsic stress exerted by the monolayers in each group correlates with cell density.
Journal ArticleDOI
Inconsistency in Graft Outcome of Bilayered Bioresorbable Supramolecular Arterial Scaffolds in Rats.
Renee Duijvelshoff,Andrea Di Luca,Eline E. van Haaften,Sylvia Dekker,Serge H. M. Söntjens,Henk M. Janssen,Anthal I.P.M. Smits,Patricia Y. W. Dankers,Carlijn V. C. Bouten +8 more
TL;DR: It remains extremely difficult to anticipate graft development and performance in vivo, so a thorough understanding of the mechanobiological mechanisms governing scaffold-driven arterial regeneration as well as potential influences of surgical procedures is warranted to further optimize scaffold designs.