R
Renee Hackenmiller
Researcher at Oregon Health & Science University
Publications - 8
Citations - 1943
Renee Hackenmiller is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Haematopoiesis & Innate immune system. The author has an hindex of 7, co-authored 8 publications receiving 1886 citations. Previous affiliations of Renee Hackenmiller include University of Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
TL;DR: Cell and tissues from Stat1(-1-1) mice were unresponsive to IFN, but remained responsive to all other cytokines tested, indicating that STAT1 appears to be specific for IFN pathways that are essential for viability in the face of otherwise innocuous pathogens.
Journal ArticleDOI
The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor
Yanzhen Cui,Renee Hackenmiller,Linnea K. Berg,François Jean,Takuya Nakayama,Gary Thomas,Jan L. Christian +6 more
TL;DR: It is shown that proBMP-4 is cleaved by furin in a sequential manner, and differential use of the upstream cleavage site could provide for tissue-specific regulation of B MP-4 activity and signaling range.
Journal ArticleDOI
Abnormal Stat Activation, Hematopoietic Homeostasis, and Innate Immunity in c-fes−/− Mice
Renee Hackenmiller,Renee Hackenmiller,Jynho Kim,Ricardo A. Feldman,M. Celeste Simon,M. Celeste Simon +5 more
TL;DR: Increased cytokine responsiveness in the absence of Fes leads to abnormal myeloid proliferation and functional defects in the macrophage lineage.
Journal ArticleDOI
Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.
Devorah C. Goldman,Renee Hackenmiller,Takuya Nakayama,Takuya Nakayama,Shailaja Sopory,Crispin Wong,Holger Kulessa,Jan L. Christian +7 more
TL;DR: It is reported that mice carrying a point mutation that prevents S2 processing show severe loss of BMP4 activity in some tissues, whereas other tissues that are sensitive to Bmp4 dosage, such as the limb, dorsal vertebrae and kidney, develop normally.
Journal ArticleDOI
Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity
Devorah C. Goldman,Renee Hackenmiller,Takuya Nakayama,Shailaja Sopory,Crispin Wong,Holger Kulessa,L. Christian +6 more
TL;DR: It is reported that mice carrying a point mutation that prevents S2 processing show severe loss of BMP4 activity in some tissues, whereas other tissues that are sensitive to Bmp4 dosage, such as the limb, dorsal vertebrae and kidney, develop normally.