Abnormal Stat Activation, Hematopoietic Homeostasis, and Innate Immunity in c-fes−/− Mice
Renee Hackenmiller,Renee Hackenmiller,Jynho Kim,Ricardo A. Feldman,M. Celeste Simon,M. Celeste Simon +5 more
TLDR
Increased cytokine responsiveness in the absence of Fes leads to abnormal myeloid proliferation and functional defects in the macrophage lineage.About:
This article is published in Immunity.The article was published on 2000-09-01 and is currently open access. It has received 73 citations till now. The article focuses on the topics: Proto-Oncogene Proteins c-fes & Myeloid.read more
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IL-13 receptors and signaling pathways: An evolving web
TL;DR: The current understanding of the IL-13 receptors and signaling pathways is summarized, supported by many in vivo observations, including that administration ofIL-13 resulted in allergic inflammation, tissue-specific overexpression of IL- 13 in the lungs of transgenic mice resulted in airway inflammation and mucus hypersecretion.
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A Critical Role for Stat3 Signaling in Immune Tolerance
Fengdong Cheng,Hongwei Wang,Alex G. Cuenca,Mei Huang,Tomar Ghansah,Jason Brayer,William G. Kerr,Kiyoshi Takeda,Shizuo Akira,Stephen P. Schoenberger,Hua Yu,Richard Jove,Eduardo M. Sotomayor +12 more
TL;DR: It is shown that Stat3 signaling plays a critical role in the induction of antigen-specific T cell tolerance, and provides a novel molecular target for manipulation of immune activation/tolerance, a central decision with profound implications in autoimmunity, transplantation, and cancer immunotherapy.
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Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense.
TL;DR: Observations demonstrate that GM-CSF has a critical role in regulation of surfactant homeostasis and alveolar macrophage innate immune functions in the lung.
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The Human and Mouse Complement of SH2 Domain Proteins—Establishing the Boundaries of Phosphotyrosine Signaling
TL;DR: This information delimits the set of SH2-containing effectors available for PTK signaling and will facilitate the systems-level analysis of pTyr-dependent protein-protein interactions and PTK-mediated signal transduction.
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Closing in on the biological functions of Fps/Fes and Fer.
TL;DR: Fps/Fes and Fer are the only known members of a distinct subfamily of the non-receptor protein-tyrosine kinase family that have roles in regulating cytoskeletal rearrangements and inside–out signalling that accompany receptor–ligand, cell–matrix and cell–cell interactions.
References
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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TL;DR: A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
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STATs and Gene Regulation
TL;DR: The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
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Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
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A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.
TL;DR: The aim in developing this micropreparation procedure was to easily and rapidly extract DNA-binding proteins from small numbers of cells, and it gives an excellent yield, comparable to that of the large scale Dignam protocol with minimal proteolysis.
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Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
TL;DR: The results of blastocyst injection studies using three independently isolated XY embryo-derived cell lines, which produce a very high proportion of live-born animals that are overtly chimaeric, are reported.