Journal ArticleDOI
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
Rüdiger Klein,Richard J. Smeyne,Wolfgang Wurst,Linda K. Long,B. Anna Auerbach,Alexandra L. Joyner,Alexandra L. Joyner,Mariano Barbacid +7 more
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Neuroanatomical examination of trkBTK (-/-) mice revealed neuronal deficiencies in the central and peripheral nervous systems, illustrating the role of the gp145trkB protein-tyrosine kinase receptor in the ontogeny of the mammalian nervous system.About:
This article is published in Cell.The article was published on 1993-10-08. It has received 685 citations till now. The article focuses on the topics: Tropomyosin receptor kinase A & Tropomyosin receptor kinase C.read more
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Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
TL;DR: It is now apparent that regulation of neuronal function by the recently identified members of the neurotrophin family is far more complex than envisioned on the basis of work with NGF, particularly for neurons in the central nervous system (CNS).
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GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
Christopher E. Henderson,Heidi S. Phillips,Richard A. Pollock,Alun M. Davies,Corinne Lemeulle,Mark Armanini,Lora C. Simpson,Barbara Moffet,Richard Vandlen,Vassilis E. Koliatsos,Arnon Rosenthal +10 more
TL;DR: Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture and to be a good candidate for treatment of motoneuron disease.
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The Trk family of neurotrophin receptors.
TL;DR: Preliminary characterization of these mutant mice has provided significant information regarding the role of these receptors in the ontogeny of the mammalian nervous system, and TrkC-deficient mice display strikingly abnormal movements consistent with loss of proprioception.
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The cellular and molecular basis of peripheral nerve regeneration.
Susan Y. Fu,Tessa Gordon +1 more
TL;DR: Axonal regeneration may be facilitated by new strategies that enhance the growth potential of neurons and optimize the growth support of the distal nerve stump in combination with prompt nerve repair.
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Mice lacking brain-derived neurotrophic factor develop with sensory deficits
TL;DR: It is shown that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion, and that BDNF is required for the survival and target innervation of particular neuronal populations.
References
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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
TL;DR: Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
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Simplified mammalian DNA isolation procedure.
TL;DR: This work has simplified the standard mammalian DNA isolation procedure with the aim of minimizing the number of manipulations required for each sample.
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The trk proto-oncogene encodes a receptor for nerve growth factor.
TL;DR: The results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor.