R
Richard N. Bergman
Researcher at Cedars-Sinai Medical Center
Publications - 489
Citations - 97005
Richard N. Bergman is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 130, co-authored 477 publications receiving 91718 citations. Previous affiliations of Richard N. Bergman include University of Southern California & University of California, Los Angeles.
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Journal ArticleDOI
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study.
Michèle M. Sale,Fang-Chi Hsu,Nicholette D. Palmer,Candace J. Gordon,Keith L. Keene,Hermina Borgerink,Arun Sharma,Richard N. Bergman,Kent D. Taylor,Mohammed F. Saad,Jill M. Norris +10 more
TL;DR: This study suggests a functional variant of UCP1 contributes to the variance of AIRg in an AA population; the plausibility of this unexpected association is supported by the novel finding that U CP1 is expressed in islets.
Journal ArticleDOI
Critical evaluation of the combined model approach for estimation of prehepatic insulin secretion
TL;DR: Monte Carlo simulation revealed that the original combined model does not provide accurate estimates of prehepatic insulin secretion under rapid kinetics, however, the extended combined model provides accurate reconstruction of pre heptic insulin secretory profile without separate quantification of C-peptide kinetics.
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
Antigone S. Dimas,Vasiliki Lagou,Adam Barker,Joshua W. Knowles,Reedik Maegi,Marie-France Hivert,Andrea Benazzo,Denis Rybin,Anne U. Jackson,Heather M. Stringham,Ci Song,Antje Fischer-Rosinsky,Trine Welløv Boesgaard,Niels Grarup,Fahim Abbasi,Themistocles L. Assimes,Ke Hao,Xia Yang,Cécile Lecoeur,Inês Barroso,Lori L. Bonnycastle,Yvonne Boettcher,Suzannah Bumpstead,Peter S. Chines,Michael R. Erdos,J. Graessler,Peter Kovacs,Mario A. Morken,Narisu Narisu,Felicity Payne,Alena Stančáková,Amy J. Swift,Anke Toenjes,Stefan R. Bornstein,Stéphane Cauchi,Philippe Froguel,David Meyre,Peter Schwarz,Hans-Ulrich Haering,Ulf Smith,Michael Boehnke,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Thomas Quertemous,Lars Lind,Torben Hansen,Oluf Pedersen,Mark Walker,Andreas Pfeiffer,Joachim Spranger,Michael Stumvoll,James B. Meigs,Nicholas J. Wareham,Johanna Kuusisto,Markku Laakso,Claudia Langenberg,Josée Dupuis,Richard M. Watanabe,Jose C. Florez,Erik Ingelsson,Mark I. McCarthy,Inga Prokopenko +63 more
TL;DR: In this article, the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processing, insulin secretion, and insulin sensitivity was examined, using additive genetic models with adjustment for sex, age, and BMI, followed by fixed-effects, inverse variance meta-analyses.
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Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study.
Margarita Teran-Garcia,Nicola Santoro,Nicola Santoro,Tuomo Rankinen,Jean Bergeron,Treva Rice,Arthur S. Leon,D. C. Rao,James S. Skinner,Richard N. Bergman,Jean-Pierre Després,Claude Bouchard +11 more
TL;DR: The LIPC -514C allele was associated with higher hepatic lipase activity in sedentary and physically active states and better Si responses to regular exercise both in black and white individuals.
Journal ArticleDOI
OOPSEG: a data smoothing program for quantitation and isolation of random measurement error.
TL;DR: A data smoothing program, OOPSEG, which automatically quantitates and filters the random measurement error in a given data series, and may have numerous applications in data analysis and experimental design.