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Richard N. Bergman

Researcher at Cedars-Sinai Medical Center

Publications -  489
Citations -  97005

Richard N. Bergman is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 130, co-authored 477 publications receiving 91718 citations. Previous affiliations of Richard N. Bergman include University of Southern California & University of California, Los Angeles.

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The modified minimal model: application to measurement of insulin sensitivity in children.

TL;DR: An abbreviated 90-min MMM test in 50 children who were siblings of patients with insulin-dependent diabetes mellitus and 7 healthy adult volunteers was performed and there was no significant difference between the SI estimated by the 2 methods provided that glucose and insulin values were interpolated at 180 min during the computer calculations of the abbreviated test.
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The trans-ancestral genomic architecture of glycemic traits

Ji Chen, +478 more
- 31 May 2021 - 
TL;DR: This paper aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available.
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FGF19 action in the brain induces insulin-independent glucose lowering

TL;DR: In ob/ob mice, it is found that systemic FGF19 administration improved glucose tolerance through its action in the brain and that a single, low-dose i.c.v. injection of F GF19 dramatically improved glucose intolerance within 2 hours.
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Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport.

TL;DR: A model in which insulin passes through an intermediate compartment en route from plasma to CSF, as a part of a specialized transport system for the delivery of insulin to the brain, best accounts for the dynamics of this uptake process.
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Diurnal Variation in Glucose Tolerance: Cyclic Suppression of Insulin Action and Insulin Secretion in Normal-Weight, But Not Obese, Subjects

TL;DR: The diurnal rhythms in insulin sensitivity and secretion in nonobese subjects are not consistent with known rhythms in growth hormone or cortisol, but could be due to the effects of a putative diurnal rhythm of sympathetic activity, which would suppress both insulin sensitivityand secretion in the evening.