R
Robert L. Modlin
Researcher at University of California, Los Angeles
Publications - 342
Citations - 45696
Robert L. Modlin is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 112, co-authored 329 publications receiving 42972 citations. Previous affiliations of Robert L. Modlin include West Los Angeles College & Howard Hughes Medical Institute.
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Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Hans Brightbill,Daniel H. Libraty,Stephan R. Krutzik,Ruey-Bing Yang,John T. Belisle,Joshua R. Bleharski,Michael Maitland,Michael V. Norgard,Scott E. Plevy,Stephen T. Smale,Patrick J. Brennan,Barry R. Bloom,Barry R. Bloom,Paul J. Godowski,Robert L. Modlin +14 more
TL;DR: It is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs), and that Activation of TLRs by microbes may initiate innate defense mechanisms against infectious pathogens.
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Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
Osamu Takeuchi,Shintaro Sato,Takao Horiuchi,Katsuaki Hoshino,Kiyoshi Takeda,Zhongyun Dong,Robert L. Modlin,Shizuo Akira +7 more
TL;DR: This paper showed that TLR1-deficient mice showed impaired proinflammatory cytokine production in response to 19-kDa lipoprotein and a synthetic triacylated lipopeptide.
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Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.
Padmini Salgame,John S. Abrams,Carol Clayberger,Harris Goldstein,Jacinto Convit,Robert L. Modlin,Barry R. Bloom +6 more
TL;DR: Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function, and interleukin-4 was found to be necessary for suppression in vitro.
Journal ArticleDOI
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger,Dennis A. Hanson,Rachel Teitelbaum,Puneet Dewan,Kayvan Niazi,Christopher J. Froelich,Tomas Ganz,Sybille Thoma-Uszynski,Agustı́n Melián,Christian Bogdan,Steven A. Porcelli,Barry R. Bloom,Alan M. Krensky,Robert L. Modlin +13 more
TL;DR: The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intrACEllular pathogens.