R
Roksana M. Pirzgalska
Researcher at Instituto Gulbenkian de Ciência
Publications - 8
Citations - 740
Roksana M. Pirzgalska is an academic researcher from Instituto Gulbenkian de Ciência. The author has contributed to research in topics: Population & White adipose tissue. The author has an hindex of 6, co-authored 7 publications receiving 562 citations. Previous affiliations of Roksana M. Pirzgalska include Howard Hughes Medical Institute & Technical University of Lisbon.
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Journal ArticleDOI
Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
Wenwen Zeng,Wenwen Zeng,Roksana M. Pirzgalska,Mafalda M.A. Pereira,Nadiya Kubasova,Andreia Barateiro,Andreia Barateiro,Elsa Seixas,Yi-Hsueh Lu,Albina Kozlova,Henning U. Voss,Gabriel G. Martins,Jeffrey M. Friedman,Jeffrey M. Friedman,Ana Domingos +14 more
TL;DR: It is found that sympathetic nerve fibers establish neuro-adipose junctions, necessary and sufficient for the induction of lipolysis in white adipose tissue and are an efferent effector of leptin action.
Journal ArticleDOI
Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine
Roksana M. Pirzgalska,Elsa Seixas,Jason S. Seidman,Verena M. Link,Verena M. Link,Noelia Martínez Sánchez,Inês Mahú,Raquel Mendes,Vitka Gres,Nadiya Kubasova,Imogen Morris,Bernardo Assein Arús,Bernardo Assein Arús,Chelsea M Larabee,Miguel Vasques,Francisco Tortosa,Ana Laura Sousa,Sathyavathy Anandan,Erin M. Tranfield,Maureen K Hahn,Matteo Iannacone,Nathanael J. Spann,Christopher K. Glass,Ana Domingos +23 more
TL;DR: This pathway is conserved, as human sympathetic ganglia also contain SAMs expressing the analogous molecular machinery for NE clearance, which thus constitutes a potential target for obesity treatment.
Journal ArticleDOI
A novel method for human hematopoietic stem/progenitor cell isolation from umbilical cord blood based on immunoaffinity aqueous two-phase partitioning.
António F. Sousa,Pedro Z. Andrade,Roksana M. Pirzgalska,Teresa M. Galhoz,Ana Azevedo,Cláudia Lobato da Silva,M. Raquel Aires-Barros,Joaquim M. S. Cabral +7 more
TL;DR: A novel cell separation process based on immunoaffinity aqueous two phase systems is presented to isolate and purify CD34+ stem/progenitor cells directly from the whole umbilical cord blood (UCB) and is expected to pave a new way to purify hematopoietic stem/ ProGenitor cells for use in a variety of clinical settings.
Journal ArticleDOI
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
Mafalda M.A. Pereira,Inês Mahú,Elsa Seixas,Noelia Martínez-Sánchez,Nadiya Kubasova,Roksana M. Pirzgalska,Paul Cohen,Marcelo O. Dietrich,Miguel López,Gonçalo J. L. Bernardes,Ana Domingos +10 more
TL;DR: A brain-sparing DT is developed, termed BRAINSPAReDT, for tissue-specific genetic ablation of cells outside the CNS using Cre drivers that are also expressed in the central nervous system (CNS).
Journal ArticleDOI
Macrophages in obesity.
TL;DR: A population of sympathetic neuron-associated macrophages (SAMs) that control obesity via the uptake and clearing of norepinephrine (NE) signaling are identified.