R
Roland J. Levinsky
Researcher at University of London
Publications - 107
Citations - 7570
Roland J. Levinsky is an academic researcher from University of London. The author has contributed to research in topics: X-linked agammaglobulinemia & Gene. The author has an hindex of 34, co-authored 106 publications receiving 7391 citations. Previous affiliations of Roland J. Levinsky include University College London & UCL Institute of Child Health.
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Journal ArticleDOI
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
David Vetrie,Vorechovský I,Paschalis Sideras,Paschalis Sideras,Jill Holland,Angela F. Davies,Frances Flinter,Lennart Hammarström,Christine Kinnon,Roland J. Levinsky,Martin Bobrow +10 more
TL;DR: A novel gene has been isolated which maps to the XLA locus, is expressed in B cells, and shows mutations in families with the disorder, the first evidence that mutations in a src-related gene are involved in human genetic disease.
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Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
Ulf Korthäuer,Daniel Graf,Hans W. Mages,Francine Brière,M Padayachee,Sue Malcolm,Alberto G. Ugazio,Luigi D. Notarangelo,Roland J. Levinsky,Richard A. Kroczek +9 more
TL;DR: Evidence is presented that point mutations in the TRAP gene give rise to nonfunctional or defective expression of TRAP on the surface of T cells in patients with HIGM1, which is responsible for the observed immunoglobulin isotype defect in HIGm1.
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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
H. Bobby Gaspar,Kathryn L. Parsley,Steven J. Howe,Doug King,Kimberly Gilmour,Kimberly Gilmour,Joanna Sinclair,Gaby Brouns,Manfred Schmidt,Christof von Kalle,Torben Barington,Marianne Antonius Jakobsen,Hans Ole Christensen,Abdulaziz Al Ghonaium,Harry N White,John L. Smith,Roland J. Levinsky,Robin R. Ali,Christine Kinnon,Adrian J. Thrasher,Adrian J. Thrasher +20 more
TL;DR: Gene therapy for SCID-X1 is a highly effective strategy for restoration of functional cellular and humoral immunity in patients with X-linked severe combined immunodeficiency.
Journal ArticleDOI
Molecular basis of opsonic defect in immunodeficient children.
M. Sumiya,P. Tabona,T Arai,J.A. Summerfield,Michael Super,Roland J. Levinsky,Malcolm W. Turner +6 more
TL;DR: Sequence analysis of the MBP gene in three children with recurrent infections, the opsonic defect, and low serum MBP concentrations showed a point mutation at base 230 of exon 1 causing a change of codon 54 from GGC to GAC.
Journal ArticleDOI
High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene
R. J. Lipscombe,M. Sumiya,Adrian V. S. Hill,Yu-Lung Lau,Roland J. Levinsky,J.A. Summerfield,Malcolm W. Turner +6 more
TL;DR: The data indicate that the two mutations have arisen independently since the divergence of African and non African populations and both have attained high frequencies.