The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition
David H. Goetz,Margaret A. Holmes,Niels Borregaard,Martin E. Bluhm,Kenneth N. Raymond,Roland K. Strong +5 more
TLDR
It is proposed that NGAL participates in the antibacterial iron depletion strategy of the innate immune system by tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent in iron-limiting conditions.About:
This article is published in Molecular Cell.The article was published on 2002-11-01 and is currently open access. It has received 1231 citations till now. The article focuses on the topics: Siderocalin & Lipocalin.read more
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Genomic Analysis of Reactive Astrogliosis
Jennifer L. Zamanian,Lijun Xu,Lynette C. Foo,Navid Nouri,Lu Zhou,Rona G. Giffard,Ben A. Barres +6 more
TL;DR: The findings provide transcriptome databases for two subtypes of reactive astrocytes that will be highly useful in generating new and testable hypotheses of their function, as well as for providing new markers to detect different types of reactiveAstrocyte reactive gliosis in human neurological diseases.
Journal ArticleDOI
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
Trude Helen Flo,Kelly D. Smith,Kelly D. Smith,Shintaro Sato,David J. Rodriguez,Margaret A. Holmes,Roland K. Strong,Shizuo Akira,Alan Aderem +8 more
TL;DR: This finding represents a new component of the innate immune system and the acute phase response to infection and limits bacterial growth by sequestrating the iron-laden siderophore.
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Cutting Edge: 1,25-dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression
Tian-Tian Wang,Frederick P. Nestel,Véronique Bourdeau,Yoshihiko Nagai,Qiuyu Wang,Jie Liao,Luz E. Tavera-Mendoza,Roberto Lin,John H. Hanrahan,Sylvie Mader,John H. White +10 more
TL;DR: 1,25(OH)2D3 thus directly regulates antimicrobial peptide gene expression, revealing the potential of its analogues in treatment of opportunistic infections.
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Siderophore-Based Iron Acquisition and Pathogen Control
TL;DR: General aspects of siderophore-mediated iron acquisition, recent findings regarding iron-related pathogen-host interactions, and current strategies for iron-dependent pathogen control will be reviewed.
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Minireview: The adipocyte - At the crossroads of energy homeostasis, inflammation, and atherosclerosis
TL;DR: The role of adipose tissue as an endocrine organ is highlighted focusing on some of the recent advances in the identification and pharmacological characterization of adipokines as well as their regulation in the context of obesity and insulin-resistant states.
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