Loïc Guillot

TL;DR: It is demonstrated that TLR3 contributes directly to the immune response of respiratory epithelial cells to influenza A virus and dsRNA, and a molecular mechanism by which these stimuli induce epithelial cell activation is proposed.

TL;DR: It is demonstrated that SP-A-induced activation of the NF-κB signaling pathway and up-regulation of cytokine synthesis such as TNF-α and IL-10 are critically dependent on the TLR4 functional complex.

TL;DR: This paper used genome-wide association analysis to identify genetic modifiers of CF lung disease, the primary cause of mortality, and provided new insights into potential targets for modulating lung disease severity in CF.

TL;DR: Data indicate that NOD2 mediates resistance to mycobacterial infection via both innate and adaptive immunity, and that Nod2 disruption led to reduced type 1 T cell activation following i.m. bacillus Calmette-Guérin infection.

TL;DR: The lung interfaces with the environment across a continuous epithelium composed of various cell types along the proximal and distal airways, which represents a physical barrier that protects from environmental insults by segregating inhaled foreign agents and regulating water and ions transport, thereby contributing to the maintenance of alveolar surface fluid balance.