X
Xin Zhang
Researcher at Second Military Medical University
Publications - 46
Citations - 2428
Xin Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Hepatocyte nuclear factors & Cancer. The author has an hindex of 19, co-authored 40 publications receiving 1907 citations. Previous affiliations of Xin Zhang include Shanghai Jiao Tong University & Chinese Center for Disease Control and Prevention.
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Journal ArticleDOI
Molecular Evolution of the SARS Coronavirus, during the Course of the SARS Epidemic in China
Jian Feng He,Guo Wen Peng,Jun Min,De Wen Yu,Wen Jia Liang,Shuyi Zhang,Rui Heng Xu,Huan Ying Zheng,Xin Wei Wu,Jun Xu,Zhan Hui Wang,Ling Fang,Xin Zhang,Hui Li,Xin Ge Yan,Jiahai Lu,Zhihong Hu,Ji Cheng Huang,Zhuo Yue Wan,Jin Lin Hou,Jin Yan Lin,Huai Dong Song,Shengyue Wang,Xiang Jun Zhou,Guo Wei Zhang,Bo Wei Gu,Huajun Zheng,Xiang Lin Zhang,Mei He,Kui Zheng,Bo Fei Wang,Gang Fu,Xiao Ning Wang,Sai Juan Chen,Zhu Chen,Zhu Chen,Pei Hao,Hua Tang,Shuang Xi Ren,Yang Zhong,Zong Ming Guo,Qi Liu,You Gang Miao,Xiangyin Kong,Wei Zhong He,Yixue Li,Chung-I Wu,Guoping Zhao,Rossa W.K. Chiu,Stephen S.C. Chim,Yu K. Tong,Paul K.S. Chan,John S. Tam,Y.M. Dennis Lo +53 more
TL;DR: The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization, and major deletions were observed in the Orf8 region of the genome at the start and the end of the epidemic.
Journal ArticleDOI
Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor‐4α gene
Chuan Yin,Yong Lin,Xin Zhang,Yue-Xiang Chen,Xin Zeng,Hai-Yan Yue,Jun-Liang Hou,Xing Deng,Jun-Ping Zhang,Ze-Guang Han,Wei-Fen Xie +10 more
TL;DR: The striking suppression effect of HNF4α on tumorigenesis and tumor development is attained by inducing the differentiation of hepatoma cells—especially CSCs—into mature hepatocytes, suggesting that differentiation therapy with H NF4α may be an effective treatment for HCC patients.
Journal ArticleDOI
Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes.
Xing Deng,Xin Zhang,Weiping Li,Ren-Xin Feng,Lu Li,Gui-Rong Yi,Xiao-Nan Zhang,Chuan Yin,Hong-Yu Yu,Jun-Ping Zhang,Bin Lu,Lijian Hui,Lijian Hui,Wei-Fen Xie,Wei-Fen Xie +14 more
TL;DR: It is shown that NPC-derived hepatocytes replenish a large fraction of the liver parenchyma following severe injuries induced by long-term thioacetamide (TAA) or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) treatment and bi-phenotypic cells were also detected in cirrhotic human livers.
Journal ArticleDOI
Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways.
Jiao Liu,Sheng Chen,Wei Wang,Bei-Fang Ning,Fei Chen,Weifeng Shen,Jin Ding,Wansheng Chen,Wei-Fen Xie,Xin Zhang +9 more
TL;DR: It is reported that CAFs promote the migration and invasion of HCC cells in vitro and facilitate the HCC metastasis to the bone, brain and lung in NOD/SCID mice.
Journal ArticleDOI
Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.
Hao Zhang,Guangchao Wang,Chen Ding,Peng Liu,Renkai Wang,Wenbin Ding,Dake Tong,Dajiang Wu,Cheng Li,Qiang Wei,Xin Zhang,Di Li,Peizhao Liu,Hao-Chen Cui,Hao Tang,Fang Ji +15 more
TL;DR: The results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy and Mechanistically, circUB AP2 was found to inhibit the expression of microRNA-143 (miR-143), thus enhancing the expression and function of anti-apoptotic Bcl-2, which is a direct target of miR- 143.