X
Xiangyin Kong
Researcher at Chinese Academy of Sciences
Publications - 159
Citations - 6451
Xiangyin Kong is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 39, co-authored 154 publications receiving 5793 citations. Previous affiliations of Xiangyin Kong include CAS-MPG Partner Institute for Computational Biology & Shanghai Jiao Tong University.
Papers
More filters
Journal ArticleDOI
Molecular Evolution of the SARS Coronavirus, during the Course of the SARS Epidemic in China
Jian Feng He,Guo Wen Peng,Jun Min,De Wen Yu,Wen Jia Liang,Shuyi Zhang,Rui Heng Xu,Huan Ying Zheng,Xin Wei Wu,Jun Xu,Zhan Hui Wang,Ling Fang,Xin Zhang,Hui Li,Xin Ge Yan,Jiahai Lu,Zhihong Hu,Ji Cheng Huang,Zhuo Yue Wan,Jin Lin Hou,Jin Yan Lin,Huai Dong Song,Shengyue Wang,Xiang Jun Zhou,Guo Wei Zhang,Bo Wei Gu,Huajun Zheng,Xiang Lin Zhang,Mei He,Kui Zheng,Bo Fei Wang,Gang Fu,Xiao Ning Wang,Sai Juan Chen,Zhu Chen,Zhu Chen,Pei Hao,Hua Tang,Shuang Xi Ren,Yang Zhong,Zong Ming Guo,Qi Liu,You Gang Miao,Xiangyin Kong,Wei Zhong He,Yixue Li,Chung-I Wu,Guoping Zhao,Rossa W.K. Chiu,Stephen S.C. Chim,Yu K. Tong,Paul K.S. Chan,John S. Tam,Y.M. Dennis Lo +53 more
TL;DR: The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization, and major deletions were observed in the Orf8 region of the genome at the start and the end of the epidemic.
Journal ArticleDOI
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP
Shangxi Xiao,Shangxi Xiao,Chuan Yu,Xueming Chou,Wenjuan Yuan,Ying Wang,Lei Bu,Lei Bu,Gang Fu,Meiqian Qian,Jun J. Yang,Yaozhou Shi,Yaozhou Shi,Landian Hu,Bin Han,Zhengmin Wang,Wei Huang,Jing Liu,Zhu Chen,Guoping Zhao,Xiangyin Kong +20 more
TL;DR: Three disease-specific mutations within the dentin sialophosphoprotein gene (DSPP) are identified and demonstrated for the first time that distinct mutations in DSPP are responsible for the clinical manifestations of DGI1 with or without DFNA39.
Journal ArticleDOI
Predicting drug-target interaction networks based on functional groups and biological features.
TL;DR: The results indicate that the network prediction system established using the Nearest Neighbor algorithm is quite promising and encouraging for drug development.
Journal ArticleDOI
Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract.
Lei Bu,Yiping Jin,Yuefeng Shi,Renyuan Chu,Airong Ban,Hans Eiberg,Lisa Andres,Haisong Jiang,Guangyong Zheng,Meiqian Qian,Bin Cui,Yu Xia,Jing Liu,Landian Hu,Guoping Zhao,Michael R. Hayden,Xiangyin Kong +16 more
TL;DR: Wang et al. as discussed by the authors carried out whole-genome linkage analysis of Chinese individuals with lamellar cataract, and found that the disorder is associated with inheritance of a 511-cM locus on chromosome 16.
Journal ArticleDOI
Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes
Ying Chen,Zhi Xu He,Ailian Liu,Kai Wang,Wen Wei Mao,Jian Xin Chu,Yong Lu,Zheng Fu Fang,Yingtang Shi,Qing Zhang Yang,Da Yuan Chen,Min Kang Wang,Jinsong Li,Shao Liang Huang,Xiangyin Kong,Yao Zhou Shi,Zhiqiang Wang,Jia Hui Xia,Zhi Gao Long,Zhi-gang Xue,Wen Xiang Ding,Hui Zhen Sheng +21 more
TL;DR: Results suggest that human somatic nuclei can form ntES cells independent of the age of the donor, and retain phenotypes similar to those of conventional human ES cells, including the ability to undergo multilineage cellular differentiation.