Q
Qi Liu
Researcher at Vanderbilt University Medical Center
Publications - 197
Citations - 9129
Qi Liu is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 35, co-authored 159 publications receiving 6224 citations. Previous affiliations of Qi Liu include Kunming Institute of Zoology & Shanghai Jiao Tong University.
Papers
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Journal ArticleDOI
Reassessment of Exosome Composition
Dennis K. Jeppesen,Aidan M. Fenix,Jeffrey L. Franklin,James N. Higginbotham,Qin Zhang,Lisa J. Zimmerman,Daniel C. Liebler,Jie Ping,Qi Liu,Rachel Evans,William H. Fissell,James G. Patton,Leonard H. Rome,Dylan T. Burnette,Robert J. Coffey,Robert J. Coffey,Robert J. Coffey +16 more
TL;DR: High-resolution density gradient fractionation and direct immunoaffinity capture are employed to precisely characterize the RNA, DNA, and protein constituents of exosomes and other non-vesicle material and show that small extracellular vesicles are not vehicles of active DNA release.
Journal ArticleDOI
Proteogenomic characterization of human colon and rectal cancer
Bing Zhang,Jing Wang,Xiaojing Wang,Jing Zhu,Qi Liu,Zhiao Shi,Matthew C. Chambers,Lisa J. Zimmerman,Kent Shaddox,Sangtae Kim,Sherri R. Davies,Sean Wang,Pei Wang,Christopher R. Kinsinger,Robert Rivers,Henry Rodriguez,R. Reid Townsend,Matthew J. Ellis,Steven A. Carr,Steven A. Carr,David L. Tabb,Robert J. Coffey,Robbert J.C. Slebos,Daniel C. Liebler,Michael A. Gillette,Karl R. Klauser,Eric Kuhn,D. R. Mani,Philipp Mertins,Karen A. Ketchum,Amanda G. Paulovich,Jeffrey R. Whiteaker,Nathan Edwards,Peter B. McGarvey,Subha Madhavan,Daniel W. Chan,Akhilesh Pandey,Ie Ming Shih,Hui Zhang,Zhen Zhang,Heng Zhu,Gordon Whiteley,Steven J. Skates,Forest M. White,Douglas A. Levine,Emily S. Boja,Tara Hiltke,Mehdi Mesri,Kenna M. Shaw,Stephen E. Stein,David Fenyö,Tao Liu,Jason E. McDermott,Samuel H. Payne,Karin D. Rodland,Richard D. Smith,Paul A. Rudnick,Michael Snyder,Yingming Zhao,Xian Chen,David F. Ransohoff,Andrew N. Hoofnagle,Melinda E. Sanders,Yue Wang,Li Ding +64 more
TL;DR: Integrated proteogenomic analysis provides functional context to interpret genomic abnormalities and affords a new paradigm for understanding cancer biology.
Journal ArticleDOI
Molecular Evolution of the SARS Coronavirus, during the Course of the SARS Epidemic in China
Jian Feng He,Guo Wen Peng,Jun Min,De Wen Yu,Wen Jia Liang,Shuyi Zhang,Rui Heng Xu,Huan Ying Zheng,Xin Wei Wu,Jun Xu,Zhan Hui Wang,Ling Fang,Xin Zhang,Hui Li,Xin Ge Yan,Jiahai Lu,Zhihong Hu,Ji Cheng Huang,Zhuo Yue Wan,Jin Lin Hou,Jin Yan Lin,Huai Dong Song,Shengyue Wang,Xiang Jun Zhou,Guo Wei Zhang,Bo Wei Gu,Huajun Zheng,Xiang Lin Zhang,Mei He,Kui Zheng,Bo Fei Wang,Gang Fu,Xiao Ning Wang,Sai Juan Chen,Zhu Chen,Zhu Chen,Pei Hao,Hua Tang,Shuang Xi Ren,Yang Zhong,Zong Ming Guo,Qi Liu,You Gang Miao,Xiangyin Kong,Wei Zhong He,Yixue Li,Chung-I Wu,Guoping Zhao,Rossa W.K. Chiu,Stephen S.C. Chim,Yu K. Tong,Paul K.S. Chan,John S. Tam,Y.M. Dennis Lo +53 more
TL;DR: The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization, and major deletions were observed in the Orf8 region of the genome at the start and the end of the epidemic.
Journal ArticleDOI
An improved method to construct basic probability assignment based on the confusion matrix for classification problem
TL;DR: An improved method to construct the BPA based on the confusion matrix is proposed that takes into account both the precision rate and the recall rate of each class.
Journal ArticleDOI
lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling
Yuanyuan Lu,Xiaodi Zhao,Xiaodi Zhao,Qi Liu,Cunxi Li,Ramona Graves-Deal,Zheng Cao,Bhuminder Singh,Jeffrey L. Franklin,Jing Wang,Huaying Hu,Tian-Ying Wei,Mingli Yang,Timothy J. Yeatman,Ethan Lee,Kenyi Saito-Diaz,Scott Hinger,James G. Patton,Christine H. Chung,Stephan Emmrich,Jan-Henning Klusmann,Daiming Fan,Robert J. Coffey,Robert J. Coffey +23 more
TL;DR: These findings identify a clinically actionable, epigenetic cause of cetuximab resistance, and describe a double-negative feedback loop between MIR100HG and the transcription factor GATA6, whereby Gata6 represses MIR 100HG, but this repression is relieved by miR-125b targeting of GATA 6.