R
Ryan S. Udan
Researcher at Baylor College of Medicine
Publications - 19
Citations - 4037
Ryan S. Udan is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Hippo signaling pathway & Light sheet fluorescence microscopy. The author has an hindex of 10, co-authored 17 publications receiving 3481 citations. Previous affiliations of Ryan S. Udan include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Bin Zhao,Xiaomu Wei,Weiquan Li,Ryan S. Udan,Ryan S. Udan,Qian Yang,Joungmok Kim,Joungmok Kim,Joe Xie,Tsuneo Ikenoue,Jindan Yu,Li Li,Li Li,Pan Zheng,Keqiang Ye,Arul M. Chinnaiyan,Georg Halder,Georg Halder,Zhi Chun Lai,Kun-Liang Guan,Kun-Liang Guan +20 more
TL;DR: It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
TL;DR: It is shown that Hippo (Hpo), the Drosophila homologue of the mammalian Ste20-like kinases, MST1/2, promotes proper termination of cell proliferation and stimulates apoptosis during development and that Sav binds to a regulatory domain of Hpo that is essential for its function.
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The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size
Maria Willecke,Maria Willecke,Fisun Hamaratoglu,Fisun Hamaratoglu,Madhuri Kango-Singh,Ryan S. Udan,Ryan S. Udan,Chiao-Lin Chen,Chunyao Tao,Xinwei Zhang,Georg Halder,Georg Halder +11 more
TL;DR: It is found that the overgrowth phenotypes of fat mutants are similar to those of mutants in Hippo pathway components: fat mutant cells continued to proliferate after wild-type cells stopped proliferating, andFat mutant cells deregulated Hippo target genes such as cyclin E and diap1.
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Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac
TL;DR: The dynamic and specific endothelial cell behaviors captured in this study reveal how sensitive endothelial cells are to changes in blood flow and how such responses drive vascular remodeling.
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Understanding vascular development
TL;DR: An overview of the development of the vascular system is provided, highlighting several areas of active investigation and key questions that remain to be answered.