R
Ryan Tewhey
Researcher at Tufts University
Publications - 52
Citations - 7044
Ryan Tewhey is an academic researcher from Tufts University. The author has contributed to research in topics: Genome & Genome-wide association study. The author has an hindex of 28, co-authored 45 publications receiving 6140 citations. Previous affiliations of Ryan Tewhey include Acıbadem University & Harvard University.
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Journal ArticleDOI
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena,Benjamin F. Voight,Valeriya Lyssenko,Noël P. Burtt,Paul I.W. de Bakker,Hong Chen,Jeffrey J. Roix,Sekar Kathiresan,Joel N. Hirschhorn,Mark J. Daly,Thomas E. Hughes,Leif Groop,David Altshuler,Peter Almgren,Jose C. Florez,Joanne M. Meyer,Kristin Ardlie,Kristina Bengtsson Boström,Bo Isomaa,Guillaume Lettre,Ulf Lindblad,Helen N. Lyon,Olle Melander,Christopher Newton-Cheh,Peter Nilsson,Marju Orho-Melander,Lennart Råstam,Elizabeth K. Speliotes,Marja-Riitta Taskinen,Tiinamaija Tuomi,Candace Guiducci,Anna Berglund,Joyce Carlson,Lauren Gianniny,Rachel Hackett,Liselotte Hall,Johan Holmkvist,Esa Laurila,Marketa Sjögren,Maria Sterner,Aarti Surti,Margareta Svensson,Malin Svensson,Ryan Tewhey,Brendan Blumenstiel,Melissa Parkin,Matthew DeFelice,Rachel Barry,Wendy Brodeur,Jody Camarata,Nancy Chia,Mary Fava,John G. Gibbons,Bob Handsaker,Claire M. Healy,Kieu Nguyen,Casey Gates,Carrie Sougnez,Diane Gage,Marcia M. Nizzari,Stacey Gabriel,Gung-Wei Chirn,Qicheng Ma,Hemang Parikh,Delwood Richardson,Darrell O. Ricke,Shaun Purcell +66 more
TL;DR: The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Journal ArticleDOI
Microdroplet-based PCR enrichment for large-scale targeted sequencing
Ryan Tewhey,Ryan Tewhey,Jason Warner,Masakazu Nakano,Masakazu Nakano,Brian Libby,Martina Medkova,Patricia H David,Steve K. Kotsopoulos,Michael L. Samuels,J. Brian Hutchison,Jonathan W. Larson,Eric J. Topol,Michael P. Weiner,Olivier Harismendy,Olivier Harismendy,Jeff Olson,Darren R. Link,Kelly A. Frazer,Kelly A. Frazer +19 more
TL;DR: An enrichment approach based on microdroplet PCR, which enables 1.5 million amplifications in parallel of specific subsets of the human genome for targeted sequencing, is described.
Journal ArticleDOI
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay
Ryan Tewhey,Ryan Tewhey,Dylan Kotliar,Dylan Kotliar,Danny S. Park,Brandon Liu,Sarah M. Winnicki,Steven K. Reilly,Steven K. Reilly,Kristian G. Andersen,Kristian G. Andersen,Tarjei S. Mikkelsen,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti,Pardis C. Sabeti +15 more
TL;DR: The massively parallel reporter assay (MPRA) is adapted to identify variants that directly modulate gene expression, using it to identify 842 variants showing differential expression between alleles, including 53 well-annotated variants associated with diseases and traits.
Journal ArticleDOI
The importance of phase information for human genomics.
Ryan Tewhey,Vikas Bansal,Vikas Bansal,Ali Torkamani,Ali Torkamani,Ali Torkamani,Eric J. Topol,Eric J. Topol,Eric J. Topol,Nicholas J. Schork,Nicholas J. Schork,Nicholas J. Schork +11 more
TL;DR: Findings indicate that relationships between human DNA sequence and phenotype, including disease, can be more fully understood with phase information, and the existing technological impediments to obtaining phase information must be overcome if human genomics is to reach its full potential.
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay
Danny S. Park,Brandon Liu,Sarah M. Winnicki,Steven K. Reilly,Kristian G. Andersen,Ryan Tewhey,Dylan Kotliar,Kristian Andersen,Tarjei S. Mikkelsen,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti +11 more
TL;DR: The massively parallel reporter assay (MPRA) is adapted to identify variants that directly modulate gene expression, and 842 variants showing differential expression between alleles are identified, including 53 well-annotated variants associated with diseases and traits.