R
Ryan Zarychanski
Researcher at University of Manitoba
Publications - 230
Citations - 12857
Ryan Zarychanski is an academic researcher from University of Manitoba. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 48, co-authored 193 publications receiving 9665 citations. Previous affiliations of Ryan Zarychanski include Winnipeg Regional Health Authority & McGill University.
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Re-framing the question: Should hydroxyethyl starch be used in clinical practice?
TL;DR: Two studies published in this issue of the Journal show how HES use changed following the Health Canada warning, and what the clinical impact of HES de-investment was in cardiac surgery.
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Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19.
Ewan C. Goligher,Patrick R. Lawler,Thomas P Jensen,Victor B. Talisa,Lindsay R. Berry,Elizabeth Lorenzi,Bryan J. McVerry,Chung-Chou H. Chang,Eric S. Leifer,Charlotte Bradbury,Jeffrey S. Berger,Beverley J. Hunt,Lana A Castellucci,Lucy Z. Kornblith,Anthony C. Gordon,Colin McArthur,Steven A R Webb,Judith S. Hochman,Matthew D. Neal,Ryan Zarychanski,Scott M. Berry,Derek C. Angus +21 more
TL;DR: In this article , the authors evaluated the effect of therapeutic-dose heparin on organ support-free days in patients hospitalized with COVID-19 in a multatform adaptive RCT.
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Effectiveness of evidence-based treatments of fetal alcohol spectrum disorders in children and adolescents: a systematic review protocol.
Deepa Singal,Chantalle Menard,Christine J. Neilson,Marni Brownell,Ana Hanlon-Dearman,Albert E. Chudley,Ryan Zarychanski,Ahmed M Abou-Setta +7 more
TL;DR: A protocol for a systematic review assessing the effectiveness of evidence from randomised controlled trials comparing fetal alcohol spectrum disorders pharmacological and non-pharmacological interventions with placebo/dummy interventions or usual standards of care in children and adolescents (<18 years old is provided.
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Association of Hydroxyethyl Starch Administration With Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation: A Systematic Review and Meta-Analysis
Ryan Zarychanski,Ahmed M Abou-Setta,Alexis Turgeon,Brett L. Houston,Lauralyn McIntyre,John C. Marshall,Dean Fergusson +6 more
TL;DR: Clinical trials and systematic reviews have suggested a greater incidence of renal damage and mortality in patients receiving hydroxyethyl starch, but these findings have been inconsistent.
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Osteonecrosis of the Jaw Associated with Pamidronate Therapy.
TL;DR: Osteonecrosis of the jaw is an important adverse outcome associated with bisphosphonate therapy and the unremitting nature of this clinical development, and the long lasting morbidity associated with it suggests that patients should be counseled regarding the possible occurrence of oste onecrosis prior to initiating therapy with pamidronate.