Ryuji Hata

TL;DR: 'ischemic tolerance' phenomenon induced by ischemic stress--which is unquestionably important--and frequent stress in clinical medicine, is intriguing and may open a new approach to investigate the pathophysiology of isChemic neuronal damage.

TL;DR: Differential manifestation of ER stress and DHA responsiveness may help explain variable clinical results obtained with the use of DHA treatment and suggests that DHA may in fact be effective for a subset of patients.

TL;DR: The present study demonstrated that the 'ischemic tolerance' phenomenon was widely found in the brain and suggested that ischemic treatment severe enough to cause HSP 72 synthesis might be needed for induction of 'iscemic tolerance'.

TL;DR: The present investigation suggests that dendrites in the vulnerable regions may be quite susceptible to ischemic stress and that the immunohistochemical procedure for microtubule-associated protein 2 may be very useful for demonstration of dendritic damage in various pathophysiological states of the central nervous system.

TL;DR: The use of multiparametric imaging techniques in this improved MCA occlusion model opens the way for advanced pathophysiological studies of stroke in gene-manipulated animals and demonstrates the feasibility of dynamic evaluations of infarct evolution.