S
Sachi S. Dholakia
Researcher at Stanford University
Publications - 15
Citations - 301
Sachi S. Dholakia is an academic researcher from Stanford University. The author has contributed to research in topics: Empty nose syndrome & Meatus. The author has an hindex of 5, co-authored 13 publications receiving 151 citations.
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Journal ArticleDOI
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
Ivan T. Lee,Tsuguhisa Nakayama,Chien-Ting Wu,Yury Goltsev,Sizun Jiang,Phillip A. Gall,Chun Kang Liao,Liang Chun Shih,Christian M. Schürch,David R. McIlwain,Pauline Chu,Nicole A. Borchard,David Zarabanda,Sachi S. Dholakia,Angela Yang,Dayoung Kim,Han Chen,Tomoharu Kanie,Chia-Der Lin,Ming Hsui Tsai,Katie M. Phillips,Raymond Kim,Jonathan B. Overdevest,Jonathan B. Overdevest,Matthew A. Tyler,Matthew A. Tyler,Carol H. Yan,Carol H. Yan,Chih Feng Lin,Yi Tsen Lin,Da Tian Bau,Gregory J. Tsay,Zara M. Patel,Yung An Tsou,Alexandar Tzankov,Matthias S. Matter,Chih Jaan Tai,Te-Huei Yeh,Peter H. Hwang,Garry P. Nolan,Jayakar V. Nayak,Peter K. Jackson +41 more
TL;DR: The discovery that the ACE2 receptor protein robustly localizes within the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission, is reported.
Posted ContentDOI
Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
Ivan T. Lee,Tsuguhisa Nakayama,Chien-Ting Wu,Yury Goltsev,Sizun Jiang,Phillip A. Gall,Chun-Kang Liao,Liang-Chun Shih,Christian M. Schürch,David R. McIlwain,Pauline Chu,Nicole A. Borchard,David Zarabanda,Sachi S. Dholakia,Angela Yang,Dayoung Kim,Tomoharu Kanie,Chia-Der Lin,Ming Hsui Tsai,Katie M. Phillips,Raymond Kim,Jonathan B. Overdevest,Matthew A. Tyler,Carol H. Yan,Chih-Feng Lin,Yi-Tsen Lin,Da Tian Bau,Gregory J. Tsay,Zara M. Patel,Yung An Tsou,Chih Jaan Tai,Te-Huei Yeh,Peter H. Hwang,Garry P. Nolan,Jayakar V. Nayak,Peter K. Jackson +35 more
TL;DR: Investigation of the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors found no evidence that the use of angiotENSin- Converting enzyme inhibitors (ACEI) or ang Elliotensin II receptor blockers (ARBs) increases ACE2 protein expression.
Journal ArticleDOI
Use of intranasal submucosal fillers as a transient implant to alter upper airway aerodynamics: implications for the assessment of empty nose syndrome.
Nicole A. Borchard,Sachi S. Dholakia,Carol H. Yan,David Zarabanda,Andrew Thamboo,Andrew Thamboo,Jayakar V. Nayak +6 more
TL;DR: Submucosal injection of a transient, resorbable filler into the inferior meatus is evaluated to favorably alter nasal aerodynamics in ENS patients.
Journal ArticleDOI
Inferior Meatus Augmentation Procedure (IMAP) to Treat Empty Nose Syndrome: A Pilot Study.
Andrew Thamboo,Andrew Thamboo,Sachi S. Dholakia,Nicole A. Borchard,Vishal Patel,Navarat Tangbumrungtham,Nathalia Velasquez,Zhenxiao Huang,David Zarabanda,Tsuguhisa Nakayama,Jayakar V. Nayak +10 more
TL;DR: IMAP can dramatically improve the quality of life of ENS patients regarding both ENS-specific symptoms and psychological well-being.
Journal ArticleDOI
Inferior meatus augmentation procedure (IMAP) normalizes nasal airflow patterns in empty nose syndrome patients via computational fluid dynamics (CFD) modeling
Jennifer Malik,Sachi S. Dholakia,Barak M Spector,Angela Yang,Dayoung Kim,Nicole A. Borchard,Andrew Thamboo,Kai Zhao,Jayakar V. Nayak +8 more
TL;DR: The inferior meatus augmentation procedure (IMAP) has been shown to effectively reduce ENS symptoms in a durable manner, but the precise mechanisms that may govern this symptomatic improvement remain unknown.