S
Sai Kiang Lim
Researcher at Agency for Science, Technology and Research
Publications - 167
Citations - 24991
Sai Kiang Lim is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Mesenchymal stem cell & Microvesicles. The author has an hindex of 52, co-authored 152 publications receiving 18269 citations. Previous affiliations of Sai Kiang Lim include Genome Institute of Singapore & National University of Singapore.
Papers
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Journal ArticleDOI
Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis
TL;DR: Proteomic and functional experiments revealed a novel role for the chromatin organizer protein HP1BP3 in mediating chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-Resistance, and self-renewal.
Patent
Method of deriving progenitor cell line
Sai Kiang Lim,Elias Lye +1 more
TL;DR: In this paper, a method comprising of providing an embryonic stem (ES) cell, and establishing a progenitor cell line from the embryonic stem cell, in order to select against somatic cells based on their inability to self-renew.
Book ChapterDOI
Isolation and Characterization of Exosome from Human Embryonic Stem Cell-Derived C-Myc-Immortalized Mesenchymal Stem Cells
Ruenn Chai Lai,Ronne Wee Yeh Yeo,Jayanthi Padmanabhan,Andre Choo,Dominique P.V. de Kleijn,Sai Kiang Lim +5 more
TL;DR: The immortalization of MSCs is described, and the production, isolation, and characterization of exosomes from immortalized MSC are described to enhance the reproducible production of therapeutic exosome production.
Journal ArticleDOI
Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation.
Bin Zhang,Ruenn Chai Lai,Wei Kian Sim,Andre Choo,Ellen Birgit Lane,Sai Kiang Lim,Sai Kiang Lim +6 more
TL;DR: In this paper, topically applied mesenchymal stem/stromal cells (MSC exosomes) were shown to inhibit complement activation in the stratum corneum and this alleviated IL-17 release by NETS from neutrophils.
Patent
Method of deriving mesenchymal stem cells
Sai Kiang Lim,Elias Lye +1 more
TL;DR: In this paper, a method of obtaining a cell culture, the method comprising providing a cell obtained by dispersing a human embryonic stem cell (hESC) colony, or a descendent thereof, and propagating the cell in the absence of a feeder cell layer in a serum free medium comprising FGF2 and optionally PDGF AB.