S
Sai Kiang Lim
Researcher at Agency for Science, Technology and Research
Publications - 167
Citations - 24991
Sai Kiang Lim is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Mesenchymal stem cell & Microvesicles. The author has an hindex of 52, co-authored 152 publications receiving 18269 citations. Previous affiliations of Sai Kiang Lim include Genome Institute of Singapore & National University of Singapore.
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Journal ArticleDOI
Exosomes for drug delivery - a novel application for the mesenchymal stem cell.
TL;DR: This work proposes human mesenchymal stem cells as the ideal cell source of exosomes for drug delivery, enabling infinite and reproducible exosome production from a single cell clone.
Journal ArticleDOI
Mesenchymal stem cell exosomes.
TL;DR: It is proposed here that MSC exosomes function as an extension of MSC's biological role as tissue stromal support cells, enabling cells to recover critical cellular functions and begin repair and regeneration.
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Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome
Ruenn Chai Lai,Soon Sim Tan,Bao Ju Teh,Siu Kwan Sze,Fatih Arslan,Dominique P.V. de Kleijn,Andre Choo,Sai Kiang Lim +7 more
TL;DR: 20S proteasome is a candidate exosome protein that could synergize with other constituents to ameliorate tissue damage and be correlated with a modest but significant reduction in oligomerized protein in a mouse model of myocardial infarction.
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Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction
Leo Timmers,Sai Kiang Lim,Imo E. Hoefer,Fatih Arslan,Ruenn Chai Lai,Angelique A M Van Oorschot,Marie-José Goumans,Chaylendra Strijder,Sui Kwan Sze,Andree Choo,Jan J. Piek,Pieter A. Doevendans,Gerard Pasterkamp,Dominique P.V. de Kleijn +13 more
TL;DR: Intravenous MSC-CM treatment after myocardial infarction increases capillary density and preserves cardiac function, probably by increasing myocardia perfusion.
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Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications
Kenneth W. Witwer,Bas W.M. van Balkom,Stefania Bruno,Andre Choo,Massimo Dominici,Mario Gimona,Andrew F. Hill,Dominique P.V. de Kleijn,M. Koh,M. Koh,Ruenn Chai Lai,S. Alex Mitsialis,Luis A. Ortiz,Eva Rohde,Takashi Asada,Wei Seong Toh,Daniel J. Weiss,Lei Zheng,Bernd Giebel,Sai Kiang Lim,Sai Kiang Lim +20 more
TL;DR: MSC-sEVs should be defined by quantifiable metrics to identify the cellular origin of the sEVs in a preparation, presence of lipid-membrane vesicles, and the degree of physical and biochemical integrity of the vesicle.