S
Sai Kiang Lim
Researcher at Agency for Science, Technology and Research
Publications - 167
Citations - 24991
Sai Kiang Lim is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Mesenchymal stem cell & Microvesicles. The author has an hindex of 52, co-authored 152 publications receiving 18269 citations. Previous affiliations of Sai Kiang Lim include Genome Institute of Singapore & National University of Singapore.
Papers
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Journal ArticleDOI
Human Embryonic Mesenchymal Stem Cell-Derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease
Arianne van Koppen,Jaap A. Joles,Bas W.M. van Balkom,Sai Kiang Lim,Dominique P.V. de Kleijn,Rachel H. Giles,Marianne C. Verhaar +6 more
TL;DR: It is demonstrated that administration of MSC-CM has a long-lasting therapeutic rescue function shown by decreased progression of CKD and reduced hypertension and glomerular injury.
Journal ArticleDOI
Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane
Soon Sim Tan,Yijun Yin,Tricia Lee,Ruenn Chai Lai,Ronne Wee Yeh Yeo,Bin Zhang,Andre Choo,Sai Kiang Lim +7 more
TL;DR: It is demonstrated that MSC exosomes are derived from endocytosed lipid rafts and that their protein cargo includes exosome-associated proteins CD81, CD9, Alix and Tsg101.
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Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration.
Jacob Ren Jie Chew,S. Chuah,K. Teo,Shipin Zhang,Ruenn Chai Lai,Jia Hui Fu,Lum Peng Lim,Sai Kiang Lim,Sai Kiang Lim,Wei Seong Toh +9 more
TL;DR: It is suggested that MSC exosome is a viable ready-to-use and cell-free MSC therapeutic for the treatment of periodontal defects and demonstrated for the first time that M SC exosomes enhance periodontAL regeneration possibly by increasing PDL migration and proliferation.
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Haptoglobin, an inflammation-inducible plasma protein.
TL;DR: The current hypothesis is that Hp exerts an anti-inflammatory activity and that by the degree with which Hp attenuates the inflammatory process, including the production of IL-6 cytokines, it determines the level and duration of acute phase expression of the Hp gene.
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Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway.
Bin Zhang,Ronne Wee Yeh Yeo,Ruenn Chai Lai,Eugene Wei Kian Sim,Keh Chuang Chin,Sai Kiang Lim +5 more
TL;DR: MSC exosome enhanced Treg production in vitro and in vivo through an APC-mediated pathway and alleviated GVHD symptoms and increased survival in mice treated with Etanercept.