S
Sai Kiang Lim
Researcher at Agency for Science, Technology and Research
Publications - 167
Citations - 24991
Sai Kiang Lim is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Mesenchymal stem cell & Microvesicles. The author has an hindex of 52, co-authored 152 publications receiving 18269 citations. Previous affiliations of Sai Kiang Lim include Genome Institute of Singapore & National University of Singapore.
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Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation
TL;DR: It is shown that male mice had lower hepatic PON-1 mRNA that increased by 170% after castration and the data suggested that this effect was testes but not plasma testosterone dependent, and antioxidant Pon-1 is regulated at the mRNA level in a gender-specific manner by proinflammatory LPS and anti-inflammatory dexamethasone.
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International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.
Verena Börger,Daniel J. Weiss,Johnathon D. Anderson,Francesc E. Borràs,Benedetta Bussolati,David R. F. Carter,Massimo Dominici,Juan M. Falcón-Pérez,Juan M. Falcón-Pérez,Mario Gimona,Andrew F. Hill,Andrew M. Hoffman,Dominique P.V. de Kleijn,Bruce L. Levine,Rebecca Lim,Jan Lötvall,S. Alex Mitsialis,Marta Monguió-Tortajada,Maurizio Muraca,Rienk Nieuwland,Anna Nowocin,Lorraine O'Driscoll,Luis A. Ortiz,Donald G. Phinney,Ilona G. Reischl,Eva Rohde,Eva Rohde,Ralf Sanzenbacher,Clotilde Théry,Wei Seong Toh,Kenneth W. Witwer,Sai Kiang Lim,Bernd Giebel +32 more
TL;DR: The International Society for Cellular and Gene Therapies and ISCT recognize the potential of extracellular vesicles from mesenchymal stromal cells and possibly other cell sources as treatments for COVID-19, but do not currently endorse the use of EVs or exosomes for any purpose in the study.
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Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease
Danny A. Kanhai,Frank L.J. Visseren,Yolanda van der Graaf,Arjan H. Schoneveld,Louise M. Catanzariti,Leo Timmers,L. Jaap Kappelle,Cuno S. P. M. Uiterwaal,Sai Kiang Lim,Siu Kwan Sze,Gerard Pasterkamp,Dominique P.V. de Kleijn +11 more
TL;DR: Cystatin C, Serpin F2 and CD14 MV levels are related to an elevated risk for future vascular events and mortality in patients with clinically manifest vascular disease.
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Proteomic Signature of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles
TL;DR: Interestingly, MSC‐EVs obtained from different sources and prepared with different methods show in vitro and in vivo therapeutic effects, indicating that isolated EVs share a common potential.
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Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles
TL;DR: The prevailing hypothesis is that stem cell EVs exert their therapeutic effects by transferring biologically active molecules from the stem cells to injured or diseased cells, and elucidation of the stem cell EV cargo would provide an insight into the multiple physiological or biochemical changes necessary to affect the many reported stem cell-based therapeutic outcomes.