S
Sai Kiang Lim
Researcher at Agency for Science, Technology and Research
Publications - 167
Citations - 24991
Sai Kiang Lim is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Mesenchymal stem cell & Microvesicles. The author has an hindex of 52, co-authored 152 publications receiving 18269 citations. Previous affiliations of Sai Kiang Lim include Genome Institute of Singapore & National University of Singapore.
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Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
TL;DR: The evidence supporting the hypothesis that transplanted MSCs secrete factors to reduce tissue injury and/or enhance tissue repair is reviewed including the recent identification of exosome as a therapeutic agent in MSC secretion.
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Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes
Jung Eun Park,Hon Sen Tan,Arnab Datta,Ruenn Chai Lai,Huoming Zhang,Wei Meng,Sai Kiang Lim,Siu Kwan Sze +7 more
TL;DR: In this article, the authors observed that tumor cells produce a secretion that modifies their microenvironment to facilitate tumor angiogenesis and metastasis under hypoxia, and the secreted proteins were predominantly cytoplasmic and membrane proteins.
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Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
Shipin Zhang,Wern Cui Chu,Ruenn Chai Lai,Sai Kiang Lim,Sai Kiang Lim,James Hoi Po Hui,Wei Seong Toh +6 more
TL;DR: This study demonstrates for the first time the efficacy of human embryonic MSCExosomes in cartilage repair, and the utility of MSC exosomes as a ready-to-use and 'cell-free' therapeutic alternative to cell-based MSC therapy.
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Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models
TL;DR: Results suggest that MSC-derived exosomes can elicit hepatoprotective effects against toxicants-induced injury, mainly through activation of proliferative and regenerative responses.
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Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.
TL;DR: A fundamental difference in the molecular mechanisms stimulating primitive and definitive erythropoiesis is suggested, demonstrating that although Epo/EpoR signaling is important for Definitive erythroid cell survival and proliferation, it is not an obligatory step in differentiation.