S
Salman F. Banani
Researcher at University of Texas Southwestern Medical Center
Publications - 6
Citations - 6006
Salman F. Banani is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications receiving 3847 citations.
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Journal ArticleDOI
Biomolecular condensates: organizers of cellular biochemistry
TL;DR: This work has shown that liquid–liquid phase separation driven by multivalent macromolecular interactions is an important organizing principle for biomolecular condensates and has proposed a physical framework for this organizing principle.
Journal ArticleDOI
Phase transitions in the assembly of multivalent signalling proteins
Pilong Li,Sudeep Banjade,Hui-Chun Cheng,Soyeon Kim,Baoyu Chen,Liang Guo,Marc C. Llaguno,Javoris Hollingsworth,David S. King,Salman F. Banani,Paul S. Russo,Qiu-Xing Jiang,B. Tracy Nixon,Michael K. Rosen +13 more
TL;DR: Interactions between diverse synthetic, multivalent macromolecules (including multi-domain proteins and RNA) produce sharp liquid–liquid-demixing phase separations, generating micrometre-sized liquid droplets in aqueous solution.
Journal ArticleDOI
Compositional Control of Phase-Separated Cellular Bodies
Salman F. Banani,Allyson M. Rice,William B. Peeples,Yuan Lin,Saumya Jain,Roy Parker,Michael K. Rosen +6 more
TL;DR: The data suggest a conceptual framework for considering the composition and control of cellular bodies assembled through heterotypic multivalent interactions, suggesting how their compositions could be controlled by levels of PML SUMOylation or cellular mRNA concentration, respectively.
Journal ArticleDOI
Genetic variation associated with condensate dysregulation in disease.
Salman F. Banani,Lena K. Afeyan,Susana Wilson Hawken,Jonathan E. Henninger,Alessandra Dall’Agnese,Victoria E. Clark,Jesse M. Platt,Ozgur Oksuz,Nancy M. Hannett,Ido Sagi,Tong Ihn Lee,Richard A. Young +11 more
TL;DR: The authors comprehensively map pathogenic mutations to condensate-promoting protein features in putative condensor-forming proteins and find over 36,000 mutations that plausibly contribute to condensor dysregulation in over 1,200 Mendelian diseases and 550 cancers.
Posted ContentDOI
Transcription factors interact with RNA to regulate genes
Ozgur Oksuz,Jonathan E. Henninger,Robert Warneford-Thomson,Ming M. Zheng,Hailey Erb,Kalon J. Overholt,Susana Wilson Hawken,Salman F. Banani,Rich Lauman,Adrienne Vancura,Anne L. Robertson,Nancy M. Hannett,Tong Ihn Lee,Leonard I. Zon,Roberto Bonasio,Richard A. Young +15 more
TL;DR: It is proposed that the ability to bind DNA, RNA and protein is a general property of many TFs and is fundamental to their gene regulatory function.