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Samuel K. Ludwin
Researcher at Montreal Neurological Institute and Hospital
Publications - 69
Citations - 26812
Samuel K. Ludwin is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Remyelination & Myelin. The author has an hindex of 34, co-authored 67 publications receiving 23050 citations. Previous affiliations of Samuel K. Ludwin include McGill University & Queen's University.
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Journal ArticleDOI
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
TL;DR: The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
Roger Stupp,Monika E. Hegi,Warren P. Mason,Martin J. van den Bent,Martin J.B. Taphoorn,Robert C. Janzer,Samuel K. Ludwin,Anouk Allgeier,Barbara Fisher,Karl Belanger,Peter Hau,Alba A. Brandes,J.M.M. Gijtenbeek,Christine Marosi,Charles J. Vecht,Karima Mokhtari,Pieter Wesseling,Salvador Villà,Elizabeth Eisenhauer,Thierry Gorlia,Michael Weller,Denis Lacombe,J. Gregory Cairncross,René-Olivier Mirimanoff +23 more
TL;DR: Benefits of adjuvant temozolomide with radiotherapy lasted throughout 5 years of follow-up, and a benefit of combined therapy was recorded in all clinical prognostic subgroups, including patients aged 60-70 years.
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An updated histological classification system for multiple sclerosis lesions
TL;DR: A simple and unifying classification of MS lesions incorporating many elements of earlier histological systems is proposed that aims to provide guidelines for neuropathologists and researchers studying MS lesions to allow for better comparison of different studies performed with MS tissue, and to aid in understanding the pathogenesis of the disease.
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Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices.
Veronique E. Miron,Samuel K. Ludwin,Peter J. Darlington,Andrew A. Jarjour,Andrew A. Jarjour,Betty Soliven,Timothy E. Kennedy,Jack P. Antel +7 more
TL;DR: Data demonstrate that fingolimod modulates multiple neuroglial cell responses, resulting in enhanced remyelination in organotypic slice cultures that maintain the complex cellular interactions of the mammalian brain.
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Classic and generalized variants of Pick's disease: A clinicopathological, ultrastructural, and immunocytochemical comparative study
TL;DR: Six sporadic cases of dementia with lobar atrophy and neuronal cytoplasmic inclusions (Pick's disease) could be separated into two groups on the basis of the involvement of subcortical structures, the distribution and the histochemical, immunochemical, and ultrastructural characteristics of the inclusions, and possibly the age at onset.