S
Samuel S. Engel
Researcher at Merck & Co.
Publications - 137
Citations - 8441
Samuel S. Engel is an academic researcher from Merck & Co.. The author has contributed to research in topics: Sitagliptin & Type 2 diabetes. The author has an hindex of 38, co-authored 134 publications receiving 7501 citations. Previous affiliations of Samuel S. Engel include Yeshiva University & Albert Einstein College of Medicine.
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Journal ArticleDOI
Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes
Jennifer B. Green,M. Angelyn Bethel,Paul W. Armstrong,John B. Buse,Samuel S. Engel,Jyotsna Garg,Robert G. Josse,Keith D. Kaufman,Joerg Koglin,Scott Korn,John M. Lachin,Darren K. McGuire,Michael J. Pencina,Eberhard Standl,Peter P. Stein,Shailaja Suryawanshi,Frans Van de Werf,Eric D. Peterson,Rury R. Holman +18 more
TL;DR: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events.
Journal ArticleDOI
Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study.
Frans J. Th. Wackers,Lawrence H. Young,Silvio E. Inzucchi,Deborah Chyun,Janice A. Davey,Eugene J. Barrett,Raymond Taillefer,Steven D. Wittlin,Gary V. Heller,Neil Filipchuk,Samuel S. Engel,Robert E. Ratner,Ami E. Iskandrian +12 more
TL;DR: Traditional and emerging cardiac risk factors and inflammatory and prothrombotic markers were not associated with abnormal stress tests, although cardiac autonomic dysfunction was a strong predictor of ischemia.
Journal ArticleDOI
Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the diabetes control and complications trial
Neil H. White,Wanjie Sun,Patricia A. Cleary,Ronald P. Danis,Matthew D. Davis,Dean P. Hainsworth,Larry D. Hubbard,John M. Lachin,David M. Nathan,Oscar B. Crofford,Jill P. Crandall,M. Phillips,M. Reid,J. Brown-Friday,Samuel S. Engel,J. Sheindlin,H. Martinez,H. Shamoon,H. Engel,William Dahms,M. Palmert,Rose Gubitosi-Klug,L. Mayer,S. Pendegras,H. Zegarra,David G. Miller,Lawrence J. Singerman,Sheila Smith-Brewer,M. Novak,P. Gaston,Saul Genuth,David J. Brillon,M. E. Lackaye,V. Reppucci,Thomas C. Lee,Murk-Hein Heinemann,Fred W. Whitehouse,M. McLellan,Davida F. Kruger,J. D. Carey,E. Angus,M. Croswell,A. Galpirn,Richard M. Bergenstal,M. Johnson,M. Spencer,K. Morgan,D. Etzwiler,David M. Kendall,D. Noller,Alan M. Jacobson,E. Golden,R. Beaser,Om P. Ganda,O. Hamdy,J. Rosenzweig,H. Wolpert,P. G. Sharuk,Paul G. Arrigg,A. Burwood,Larry Rand,Mary E. Larkin,John E. Godine,D. Moore,Enrico Cagliero,P. Lou,S. Fritz,G. Ziegler,John M. Pach,R. Colligan,Maria F. Lopes-Virella,John A. Colwell,Kathie L. Hermayer,M. Brabham,J. Soule,A. Blevins,J. Parker,David A. Lee,P. Lindsey,M. Bracey,K. Lee,M. Nutaitis,A. Farr,S. Elsing,T. Thompson,J. Selby,Timothy J. Lyons,S. Yacoub-Wasef,M. Szpiech,D. Wood,Ronald K. Mayfield,Mark E. Molitch,B. Schaefer,Lee M. Jampol,Alice T. Lyon,Manjot K. Gill,Z. Strugula,L. Kaminski,Jonathan Shankle,P. Astlesford,D. Blackburn,Senda Ajroud-Driss,O. Stone,C. West,Inger Burnett-Zeigler,Orville G. Kolterman,Gayle M. Lorenzi,Michael H. Goldbaum,K. Harvey,Henry Ferreyra,William I. Sivitz,Margaret L. Bayless,Thomas A. Weingeist,Edwin M. Stone,H. Culver Boldt,K. Gehres,Stephen R. Russell,J. Bayless,J. Kramer,J. Long,R. Zeither,M. Hebdon,Thomas Donner,S. Johnsonbaugh,J. Gordon,Ramzi K. Hemady,A. Kowarski,D. Ostrowski,Scott M. Steidl,B. Jones,D. Counts,William H. Herman,Catherine L. Martin,Rodica Pop-Busui,Andrew K. Vine,Susan G. Elner,Eva L. Feldman,James W. Albers,Douglas A. Greene,Martin J. Stevens,John P. Bantle,B. Rogness,Timothy W. Olsen,E. Steuer,Pamela Rath,S. Hitt,J. Giangiacom,David E. Goldstein,David S. Schade,J. L. Canady,J. M. Schluter,Arup Das,D. Hornbeck,Sharon B. Schwartz,P. A. Bourne,Barbara J. Maschak-Carey,L. Baker,S. Braunstein,Alexander J. Brucker,Trevor J. Orchard,N. Silvers,Christopher M. Ryan,Thomas J. Songer,Bernard H. Doft,Shelly Olson,Robert Bergren,Louis A. Lobes,P. Paczan Rath,D. J. Becker,Allan L. Drash,Anthony D. Morrison,J. Vaccaro-Kish,M. L. Bernal,John I. Malone,Peter R. Pavan,N. Grove,M. N. Iyer,A. F. Burrows,E. A. Tanaka,R. Gstalder,Samuel Dagogo-Jack,C. Wigley,H. Ricks,Abbas E. Kitabchi,M. B. Murphy,S. Moser,D. Meyer,A. Iannacone,Edward Chaum,S. Yoser,Michael Bryer-Ash,S. Schussler,Helen Lambeth,Philip Raskin,S. Strowig,R. Ufret,Yu-Guang He,A. Edwards,J. Alappatt,C. Wilson,S. Park,B. Zinman,Annette Barnie,S. MacLean,R. Devenyi,Mark S. Mandelcorn,M. Brent,S. Rogers,A. Gordon,Jerry P. Palmer,S. Catton,John D. Brunzell,J. Ginsberg,James L. Kinyoun,L. Van Ottingham,John Dupre,J. Harth,David A. Nicolle,C. Canny,M. May,Janie Lipps,Anupam Agarwal,T. Adkins,L. Survant,Rodney A. Lorenz,Stephen S. Feman,Lucy A. Levandoski,Isaac Boniuk,G. Grand,Matthew A. Thomas,Dean B. Burgess,Daniel P. Joseph,Kevin J. Blinder,Gaurav K. Shah,Julio V. Santiago,William V. Tamborlane,Patricia Gatcomb,K. Stoessel,K. Taylor,R. Trail,J. Quin,D. Kenny,Jye-Yu C. Backlund,Brandy N. Rutledge,Barbara H. Waberski,K. Klumpp,K. Chan,Lisa Diminick,D. Rosenberg,B. Petty,A. Determan,C. Williams,L. Dews,M. Hawkins,C. Cowie,J. Fradkin,C. Siebert,R. Eastman,P. Geithman,L. Kastorff,Michael W. Neider,D. Badal,Barbara Esser,K. Miner,Hugh D. Wabers,Kathy Glander,Jeffrey M. Joyce,Nancy L. Robinson,C. Hurtenbach,C. Hannon,Michael W. Steffes,Jean M. Bucksa,Blanche M. Chavers,Daniel H. O'Leary,L. Funk,Joseph F. Polak,Anita Harrington,Richard S. Crow,B. Gloeb,S. Thomas,C. O'Donnell,Ronald J. Prineas,Charles Campbell,D. Sandstrom,T. Williams,M. Geckle,E. Cupelli,F. Thoma,B. Burzuk,T. Woodfill,P. Low,C. Sommer,K. Nickander,Robert Detrano,N. Wong,M. Fox,L. Kim,R. Oudiz,Gordon C. Weir,C. Clark,R. D'Agostino,M. Espeland,Barbara E. K. Klein,T. Manolio,D. Singer,M. Stern,W. T. Garvey,Alicia J. Jenkins,Ronald Klein,Gabriel Virella,Ayad A. Jaffa,Daniel T. Lackland,Daniel L. McGee,D. Zheng,Andrew M. Paterson,Andrew P. Boright,Shelley B. Bull,L. Sun,S. Scherer,John E. Hokanson,Santica M. Marcovina,Jonathan Q. Purnell,Shalamar D. Sibley,Samir S. Deeb,Kate Edwards +324 more
TL;DR: The persistent difference in diabetic retinopathy between former intensive and conventional therapy ("metabolic memory") continues for at least 10 years but may be waning.
Journal ArticleDOI
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes
Tina Vilsbøll,Julio Rosenstock,Hannele Yki-Järvinen,William T. Cefalu,Y. Chen,E. Luo,Bret J. Musser,Paula J. Andryuk,Y. Ling,Keith D. Kaufman,John M. Amatruda,Samuel S. Engel,L. Katz +12 more
TL;DR: The objective is to evaluate the efficacy and tolerability of sitagliptin when added to insulin therapy alone or in combination with metformin in patients with type 2 diabetes.
Journal ArticleDOI
Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus
Kristy Iglay,Hakima Hannachi,Patrick Joseph Howie,Jinfei Xu,Xueying Li,Samuel S. Engel,Lori Moore,Swapnil Rajpathak +7 more
TL;DR: The vast majority of patients with T2DM have multiple comorbidities, and the presence of multimorbidity should be considered in the context of clinical decision making.