S
Sara Alaei
Researcher at Australian Regenerative Medicine Institute
Publications - 12
Citations - 1222
Sara Alaei is an academic researcher from Australian Regenerative Medicine Institute. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 7, co-authored 10 publications receiving 1048 citations. Previous affiliations of Sara Alaei include Discovery Institute & Monash University.
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Journal ArticleDOI
A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Jose M. Polo,Endre Anderssen,Endre Anderssen,Ryan M. Walsh,Benjamin A. Schwarz,Christian M. Nefzger,Sue Mei Lim,Marti Borkent,Marti Borkent,Effie Apostolou,Sara Alaei,Jennifer Cloutier,Ori Bar-Nur,Sihem Cheloufi,Matthias Stadtfeld,Maria E. Figueroa,Daisy A. Robinton,Sridaran Natesan,Ari Melnick,Jinfang Zhu,Sridhar Ramaswamy,Sridhar Ramaswamy,Konrad Hochedlinger,Konrad Hochedlinger +23 more
TL;DR: This integrative analysis allowed us to identify genes that act as roadblocks during reprogramming and surface markers that further enrich for cells prone to forming iPSCs, and offer new mechanistic insights into the nature and sequence of molecular events inherent to cellular reprograming.
Journal ArticleDOI
Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1
Phong D. Nguyen,Georgina E Hollway,Carmen Sonntag,Lee B. Miles,Thomas E. Hall,Silke Berger,Kristine J. Fernandez,David B. Gurevich,Nicholas J. Cole,Sara Alaei,Mirana Ramialison,Robert L. Sutherland,Robert L. Sutherland,Jose M. Polo,Graham J. Lieschke,Peter D. Currie +15 more
TL;DR: The molecular basis for a novel somite lineage restriction mechanism is revealed and a new paradigm in induction of definitive HSCs is defined, which generates a dramatic increase in chemokine-dependent HSC induction.
Journal ArticleDOI
Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming.
Anja S Knaupp,Anja S Knaupp,Anja S Knaupp,Sam Buckberry,Sam Buckberry,Jahnvi Pflueger,Jahnvi Pflueger,Sue Mei Lim,Sue Mei Lim,Sue Mei Lim,Ethan Ford,Ethan Ford,Michael R. Larcombe,Michael R. Larcombe,Michael R. Larcombe,Fernando J. Rossello,Fernando J. Rossello,Fernando J. Rossello,Alex de Mendoza,Alex de Mendoza,Sara Alaei,Sara Alaei,Sara Alaei,Jaber Firas,Jaber Firas,Jaber Firas,Melissa L. Holmes,Melissa L. Holmes,Melissa L. Holmes,Shalima S. Nair,Shalima S. Nair,Susan J. Clark,Susan J. Clark,Christian M. Nefzger,Christian M. Nefzger,Christian M. Nefzger,Ryan Lister,Ryan Lister,Jose M. Polo,Jose M. Polo,Jose M. Polo +40 more
TL;DR: This comprehensive characterization of reprogramming-associated molecular changes broadens the understanding of this process and sheds light on how TFs access and change the chromatin during cell-fate transitions.
Journal ArticleDOI
Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest.
Phong D. Nguyen,David B. Gurevich,Carmen Sonntag,Lucy Hersey,Sara Alaei,Hieu T. Nim,Ashley L. Siegel,Thomas E. Hall,Fernando J. Rossello,Fernando J. Rossello,Sarah Elizabeth Boyd,Sarah Elizabeth Boyd,Jose M. Polo,Jose M. Polo,Peter D. Currie,Peter D. Currie +15 more
TL;DR: It is revealed that distinct regulatory mechanisms orchestrate stem cell dynamics during organ growth, beyond the G0/G1 cell-cycle inhibition traditionally associated with maintaining tissue-resident stem cells.
Journal ArticleDOI
Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors
Shiva Nemati,Maryam Hatami,Sahar Kiani,Katayoun Hemmesi,H Gourabi,Najmehsadat Masoudi,Sara Alaei,Hossein Baharvand,Hossein Baharvand +8 more
TL;DR: A homogenous, expandable, and self-renewable population of multipotent NPs from hiPSCs, using an adherent system and defined medium supplemented with a combination of factors to create patient-specific neural progenitors.