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Sara Verbandt
Researcher at Katholieke Universiteit Leuven
Publications - 12
Citations - 822
Sara Verbandt is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Transcriptome & Stromal cell. The author has an hindex of 6, co-authored 8 publications receiving 273 citations.
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Journal ArticleDOI
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.
Hae Ock Lee,Hae Ock Lee,Yourae Hong,Yourae Hong,Hakki Emre Etlioglu,Yong Beom Cho,Yong Beom Cho,Valentina Pomella,Ben Van den Bosch,Jasper Vanhecke,Sara Verbandt,Hyekyung Hong,Jae Woong Min,Nayoung K.D. Kim,Nayoung K.D. Kim,Hye Hyeon Eum,Hye Hyeon Eum,Junbin Qian,Bram Boeckx,Diether Lambrechts,Petros Tsantoulis,Gert De Hertogh,Woosung Chung,Taeseob Lee,Taeseob Lee,Minae An,Minae An,Hyun Tae Shin,Je-Gun Joung,Min Hyeok Jung,Gunhwan Ko,Pratyaksha Wirapati,Seok-Hyung Kim,Hee Cheol Kim,Seong Hyeon Yun,Iain Beehuat Tan,Iain Beehuat Tan,Bobby Ranjan,Woo Yong Lee,Tae-You Kim,Jung Kyoon Choi,Young Joon Kim,Shyam Prabhakar,Sabine Tejpar,Woong-Yang Park,Woong-Yang Park +45 more
TL;DR: The collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.
Journal ArticleDOI
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.
Junbin Qian,Siel Olbrecht,Bram Boeckx,Hanne Vos,Damya Laoui,Emre Etlioglu,Els Wauters,Valentina Pomella,Sara Verbandt,Pieter Busschaert,Ayse Bassez,A. Franken,Marlies Vanden Bempt,Jieyi Xiong,Birgit Weynand,Yannick Van Herck,Asier Antoranz,Francesca Maria Bosisio,Bernard Thienpont,Giuseppe Floris,Ignace Vergote,Ann Smeets,Sabine Tejpar,Diether Lambrechts +23 more
TL;DR: This work profiles 233,591 single cells from patients with lung, colorectal, ovary and breast cancer and constructs a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies, generating the first panoramic view on the shared complexity of stronal cells in different cancers.
Posted ContentDOI
A Pan-Cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling
Junbin Qian,Siel Olbrecht,Bram Boeckx,Hanne Vos,Damya Laoui,Emre Etlioglu,Els Wauters,Valentina Pomella,Sara Verbandt,Pieter Busschaert,Ayse Bassez,A. Franken,Marlies Vanden Bempt,Jieyi Xiong,Birgit Weynand,Yannick Van Herck,Asier Antoranz,Francesca Maria Bosisio,Bernard Thienpont,Giuseppe Floris,Ignace Vergote,Ann Smeets,Sabine Tejpar,Diether Lambrechts +23 more
TL;DR: A first panoramic view on the shared complexity of stromal cells in different cancers is generated by providing a comprehensive blueprint through an interactive web server.
Journal ArticleDOI
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
Ignasius Joanito,Pratyaksha Wirapati,Nancy Zhao,Zahid Nawaz,Grace Yeo,Fiona Yi Xin Lee,Christine L. P. Eng,Dominique Camat Macalinao,Merve Kahraman,Harini Srinivasan,Vairavan Lakshmanan,Sara Verbandt,Petros Tsantoulis,Nicole Ann L. Gunn,Prasanna Nori Venkatesh,Zhong Wee Poh,Rahul Nahar,Hsueh Ling Janice Oh,Jia Min Loo,Shumei Chia,Lih Feng Cheow,Elsie Cheruba,Michael Wong,Lindsay Kua,Clarinda Chua,Andy Nguyen,Justin Golovan,Anna Gan,Wan Jun Lim,Yu Guo,Choon Kong Yap,Brenda Tay,Yourae Hong,Dawn Q. Chong,Aik-Yong Chok,Woong-Yang Park,Shuting Han,Mei-Huan Chang,Isaac Seow-En,Cherylin Fu,Ronnie Mathew,Ee-Lin Toh,Lewis Z. Hong,Anders Jacobsen Skanderup,Ramanuj DasGupta,Chin-Ann Johnny Ong,Kiat Hon Lim,Emile Kwong Wei Tan,Si-Lin Koo,Wei Qiang Leow,Sabine Tejpar,Shyam Prabhakar,Iain Beehuat Tan +52 more
TL;DR: In this paper , the consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics and two intrinsic subtypes, iCMS2 and ICMS3, refine CMS.
Journal ArticleDOI
Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources.
Bram Cerulus,Abbas Jariani,Gemma Perez-Samper,Lieselotte Vermeersch,Julian M. J. Pietsch,Matthew M. Crane,Matthew M. Crane,Aaron M. New,Brigida Gallone,Miguel Roncoroni,Maria C Dzialo,Sander K. Govers,Jhana O Hendrickx,Eva Galle,Maarten Coomans,Pieter Berden,Sara Verbandt,Peter S. Swain,Kevin J. Verstrepen +18 more
TL;DR: How trans-generational transitions in central carbon metabolism generate history-dependent behavior in yeast is revealed, and the molecular toolbox of Saccharomyces cerevisiae is used to provide a mechanistic framework for similar phenomena in other cell types.