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Woosung Chung
Researcher at Samsung Medical Center
Publications - 10
Citations - 1579
Woosung Chung is an academic researcher from Samsung Medical Center. The author has contributed to research in topics: Transcriptome & Cancer. The author has an hindex of 8, co-authored 10 publications receiving 952 citations. Previous affiliations of Woosung Chung include Sungkyunkwan University.
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Journal ArticleDOI
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
Woosung Chung,Hye Hyeon Eum,Hye Hyeon Eum,Hae Ock Lee,Hae Ock Lee,Kyung Min Lee,Han-Byoel Lee,Kyu-Tae Kim,Han Suk Ryu,Sangmin Kim,Jeong Eon Lee,Yeon Hee Park,Zhengyan Kan,Wonshik Han,Woong-Yang Park,Woong-Yang Park +15 more
TL;DR: The results illustrate that the breast cancer transcriptome has a wide range of intratumoral heterogeneity, which is shaped by the tumour cells and immune cells in the surrounding microenvironment.
Journal ArticleDOI
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.
Hae Ock Lee,Hae Ock Lee,Yourae Hong,Yourae Hong,Hakki Emre Etlioglu,Yong Beom Cho,Yong Beom Cho,Valentina Pomella,Ben Van den Bosch,Jasper Vanhecke,Sara Verbandt,Hyekyung Hong,Jae Woong Min,Nayoung K.D. Kim,Nayoung K.D. Kim,Hye Hyeon Eum,Hye Hyeon Eum,Junbin Qian,Bram Boeckx,Diether Lambrechts,Petros Tsantoulis,Gert De Hertogh,Woosung Chung,Taeseob Lee,Taeseob Lee,Minae An,Minae An,Hyun Tae Shin,Je-Gun Joung,Min Hyeok Jung,Gunhwan Ko,Pratyaksha Wirapati,Seok-Hyung Kim,Hee Cheol Kim,Seong Hyeon Yun,Iain Beehuat Tan,Iain Beehuat Tan,Bobby Ranjan,Woo Yong Lee,Tae-You Kim,Jung Kyoon Choi,Young Joon Kim,Shyam Prabhakar,Sabine Tejpar,Woong-Yang Park,Woong-Yang Park +45 more
TL;DR: The collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.
Journal ArticleDOI
Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells
Kyu-Tae Kim,Kyu-Tae Kim,Hye Won Lee,Hae-Ock Lee,Hae-Ock Lee,Sang Cheol Kim,Yun Jee Seo,Woosung Chung,Woosung Chung,Hye Hyeon Eum,Hye Hyeon Eum,Do-Hyun Nam,Do-Hyun Nam,Junhyong Kim,Kyeung Min Joo,Kyeung Min Joo,Woong-Yang Park,Woong-Yang Park +17 more
TL;DR: Single-cell RNA-seq on viable PDX cells identified a candidate tumor cell subgroup associated with anti- cancer drug resistance, a powerful approach for identifying unique tumor cell-specific gene expression profiles which could facilitate the development of optimized clinical anti-cancer strategies.
Journal ArticleDOI
Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures
Zhengyan Kan,Ying Ding,Jin-Ho Kim,Hae Hyun Jung,Woosung Chung,Samir Lal,Soonweng Cho,Julio Fernandez-Banet,Se Kyung Lee,Seok Won Kim,Jeong Eon Lee,Yoon-La Choi,Shibing Deng,Ji-Yeon Kim,Jin Seok Ahn,Ying Sha,Xinmeng Jasmine Mu,Jae-Yong Nam,Young-Hyuck Im,Soo-Hyeon Lee,Woong-Yang Park,Seok Jin Nam,Yeon Hee Park +22 more
TL;DR: It is revealed that Korean BC status is independently associated with increased TIL and decreased TGF-β signaling expression signatures, suggesting that younger Asian BCs harbor more immune-active microenvironment than western BCs.
Journal ArticleDOI
Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient
Hye Won Lee,Woosung Chung,Hae-Ock Lee,Hae-Ock Lee,Da Eun Jeong,Areum Jo,Joung Eun Lim,Jeong Hee Hong,Do-Hyun Nam,Do-Hyun Nam,Byong Chang Jeong,Byong Chang Jeong,Se Hoon Park,Kyeung Min Joo,Woong-Yang Park,Woong-Yang Park +15 more
TL;DR: A single case report demonstrating the power of scRNA-seq for visualizing the tumor microenvironment and identifying molecular and cellular therapeutic targets in a treatment-refractory cancer patient is presented.