V
Valentina Pomella
Researcher at Katholieke Universiteit Leuven
Publications - 8
Citations - 752
Valentina Pomella is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Stromal cell & Cancer cell. The author has an hindex of 5, co-authored 7 publications receiving 274 citations.
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Journal ArticleDOI
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.
Hae Ock Lee,Hae Ock Lee,Yourae Hong,Yourae Hong,Hakki Emre Etlioglu,Yong Beom Cho,Yong Beom Cho,Valentina Pomella,Ben Van den Bosch,Jasper Vanhecke,Sara Verbandt,Hyekyung Hong,Jae Woong Min,Nayoung K.D. Kim,Nayoung K.D. Kim,Hye Hyeon Eum,Hye Hyeon Eum,Junbin Qian,Bram Boeckx,Diether Lambrechts,Petros Tsantoulis,Gert De Hertogh,Woosung Chung,Taeseob Lee,Taeseob Lee,Minae An,Minae An,Hyun Tae Shin,Je-Gun Joung,Min Hyeok Jung,Gunhwan Ko,Pratyaksha Wirapati,Seok-Hyung Kim,Hee Cheol Kim,Seong Hyeon Yun,Iain Beehuat Tan,Iain Beehuat Tan,Bobby Ranjan,Woo Yong Lee,Tae-You Kim,Jung Kyoon Choi,Young Joon Kim,Shyam Prabhakar,Sabine Tejpar,Woong-Yang Park,Woong-Yang Park +45 more
TL;DR: The collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.
Journal ArticleDOI
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.
Junbin Qian,Siel Olbrecht,Bram Boeckx,Hanne Vos,Damya Laoui,Emre Etlioglu,Els Wauters,Valentina Pomella,Sara Verbandt,Pieter Busschaert,Ayse Bassez,A. Franken,Marlies Vanden Bempt,Jieyi Xiong,Birgit Weynand,Yannick Van Herck,Asier Antoranz,Francesca Maria Bosisio,Bernard Thienpont,Giuseppe Floris,Ignace Vergote,Ann Smeets,Sabine Tejpar,Diether Lambrechts +23 more
TL;DR: This work profiles 233,591 single cells from patients with lung, colorectal, ovary and breast cancer and constructs a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies, generating the first panoramic view on the shared complexity of stronal cells in different cancers.
Posted ContentDOI
A Pan-Cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling
Junbin Qian,Siel Olbrecht,Bram Boeckx,Hanne Vos,Damya Laoui,Emre Etlioglu,Els Wauters,Valentina Pomella,Sara Verbandt,Pieter Busschaert,Ayse Bassez,A. Franken,Marlies Vanden Bempt,Jieyi Xiong,Birgit Weynand,Yannick Van Herck,Asier Antoranz,Francesca Maria Bosisio,Bernard Thienpont,Giuseppe Floris,Ignace Vergote,Ann Smeets,Sabine Tejpar,Diether Lambrechts +23 more
TL;DR: A first panoramic view on the shared complexity of stromal cells in different cancers is generated by providing a comprehensive blueprint through an interactive web server.
Journal ArticleDOI
Velour trial biomarkers update: Impact of RAS, BRAF, and sidedness on aflibercept activity.
Pratyaksha Wirapati,Valentina Pomella,Ben Vandenbosch,Peter Kerr,Evaristo Maiello,Grahame Mark Jeffery,Razvan-Ovidiu D. Curca,Meinolf Karthaus,John Bridgewater,Anca C. Mihailov,Igor Kiss,Sandra Merino,Joseph McKendrick,Zacharenia Saridaki,Xavier Sagaert,Sabine Tejpar +15 more
TL;DR: Addition of (ziv)-aflibercept (A) to FOLFIRI in second-line therapy for metastatic colorectal cancer (CRC) has been shown to be beneficial in phase III VELOUR trial (NCT00561470).
Journal ArticleDOI
Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells.
Albert Bosch-Vilaró,Bart Jacobs,Valentina Pomella,Layka Abbasi Asbagh,Richard Kirkland,Joe Michel,Sharat Singh,Xinjun Liu,Phillip Kim,Gregory Weitsman,Paul R. Barber,Borivoj Vojnovic,Borivoj Vojnovic,Tony Ng,Tony Ng,Sabine Tejpar +15 more
TL;DR: Evidence of the limited effectiveness of cetuximab monotherapy compared to rational combinations is provided and the existence of a cetukimab-induced feedback HER3 activation that could potentially result in reduced cetUXimab efficacy in colorectal cancer patients is suggested.