S
Sasha R. Azar
Researcher at University of Texas Medical Branch
Publications - 23
Citations - 807
Sasha R. Azar is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Zika virus & Chikungunya. The author has an hindex of 12, co-authored 23 publications receiving 516 citations.
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Journal ArticleDOI
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Isabel Rodriguez-Barraquer,Federico Costa,Federico Costa,Federico Costa,Eduardo J. M. Nascimento,Nivison Ruy Rocha Nery Junior,Nivison Ruy Rocha Nery Junior,Priscila M. S. Castanha,Priscila M. S. Castanha,Gielson Almeida do Sacramento,Jaqueline S. Cruz,Mayara Carvalho,Daiana De Olivera,José E. Hagan,José E. Hagan,Haritha Adhikarla,Elsio A. Wunder,Elsio A. Wunder,Danilo F. Coêlho,Danilo F. Coêlho,Sasha R. Azar,Shannan L. Rossi,Nikos Vasilakis,Scott C. Weaver,Guilherme S. Ribeiro,Guilherme S. Ribeiro,Angel Balmaseda,Eva Harris,Maurício Lacerda Nogueira,Mitermayer G. Reis,Mitermayer G. Reis,Mitermayer G. Reis,Ernesto T. A. Marques,Ernesto T. A. Marques,Derek A. T. Cummings,Albert I. Ko,Albert I. Ko +36 more
TL;DR: Zika transmission within a Brazilian slum community indicates that prior dengue immunity and local variations influence transmission, and the landscape of ZIKV immunity that now exists may affect the risk for future transmission.
Journal ArticleDOI
Variation in Aedes aegypti Mosquito Competence for Zika Virus Transmission.
Christopher M. Roundy,Sasha R. Azar,Shannan L. Rossi,Jing H. Huang,Grace Leal,Ruimei Yun,Ildefonso Fernández-Salas,Christopher J. Vitek,Igor A.D. Paploski,Uriel Kitron,Guilherme S. Ribeiro,Kathryn A. Hanley,Scott C. Weaver,Nikos Vasilakis +13 more
TL;DR: Although regional origins of vector populations and virus strain influence transmission efficiency, Ae.
Journal ArticleDOI
Envelope Protein Ubiquitination Drives Entry and Pathogenesis of Zika Virus
Maria Isabel Giraldo,Maria Isabel Giraldo,Hongjie Xia,Leopoldo Aguilera-Aguirre,Adam Hage,Sarah van Tol,Chao Shan,Xuping Xie,Gail L. Sturdevant,Shelly J. Robertson,Kristin L. McNally,Kimberly Meade-White,Sasha R. Azar,Shannan L. Rossi,Wendy Maury,Michael Woodson,Holly Ramage,Jeffrey R. Johnson,Nevan J. Krogan,Marc C. Morais,Sonja M. Best,Pei Yong Shi,Ricardo Rajsbaum +22 more
TL;DR: It is demonstrated that the ubiquitination of ZikV E is an important determinant of virus entry, tropism and pathogenesis, and monoclonal antibodies against K63-linked polyubiquitin specifically neutralize ZIKV and reduce viraemia in mice.
Journal ArticleDOI
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission.
Chao Shan,Hongjie Xia,Sherry L. Haller,Sasha R. Azar,Yang Liu,Jianying Liu,Antonio E. Muruato,Rubing Chen,Shannan L. Rossi,Maki Wakamiya,Nikos Vasilakis,Rongjuan Pei,Camila R. Fontes-Garfias,Sanjay K. Singh,Xuping Xie,Scott C. Weaver,Pei Yong Shi +16 more
TL;DR: Overall, this study revealed E-V473M as a critical determinant for enhanced ZIKV virulence, intrauterine transmission during pregnancy, and viremia to facilitate urban transmission.
Journal ArticleDOI
Vector Competence: What Has Zika Virus Taught Us?
Sasha R. Azar,Scott C. Weaver +1 more
TL;DR: The various techniques and considerations intrinsic to vector competence studies are reviewed, with respect to contemporary findings for ZIKV, as well as historical findings for other arboviruses, and potential avenues of standardization going forward are discussed.