Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Isabel Rodriguez-Barraquer,Federico Costa,Federico Costa,Federico Costa,Eduardo J. M. Nascimento,Nivison Ruy Rocha Nery Junior,Nivison Ruy Rocha Nery Junior,Priscila M. S. Castanha,Priscila M. S. Castanha,Gielson Almeida do Sacramento,Jaqueline S. Cruz,Mayara Carvalho,Daiana De Olivera,José E. Hagan,José E. Hagan,Haritha Adhikarla,Elsio A. Wunder,Elsio A. Wunder,Danilo F. Coêlho,Danilo F. Coêlho,Sasha R. Azar,Shannan L. Rossi,Nikos Vasilakis,Scott C. Weaver,Guilherme S. Ribeiro,Guilherme S. Ribeiro,Angel Balmaseda,Eva Harris,Maurício Lacerda Nogueira,Mitermayer G. Reis,Mitermayer G. Reis,Mitermayer G. Reis,Ernesto T. A. Marques,Ernesto T. A. Marques,Derek A. T. Cummings,Albert I. Ko,Albert I. Ko +36 more
TLDR
Zika transmission within a Brazilian slum community indicates that prior dengue immunity and local variations influence transmission, and the landscape of ZIKV immunity that now exists may affect the risk for future transmission.Abstract:
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.read more
Citations
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A perspective on potential antibody-dependent enhancement of SARS-CoV-2.
Ann M. Arvin,Katja Fink,Michael A. Schmid,Andrea L. Cathcart,Roberto Spreafico,Colin Havenar-Daughton,Antonio Lanzavecchia,Davide Corti,Herbert W. Virgin +8 more
TL;DR: It will be essential to depend on careful analysis of safety in humans as immune interventions for COVID-19 move forward, because ADE of disease cannot be reliably predicted after either vaccination or treatment with antibodies.
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Zika Virus Infection — After the Pandemic
TL;DR: Aedes aegypti is a mosquito-borne flavivirus that can cause congenital defects, including microcephaly, and the virus can be passed to animals through contact chemoreception and sexual transmission.
Journal ArticleDOI
Zika virus infection enhances future risk of severe dengue disease
Leah C. Katzelnick,César Narvaez,Sonia Arguello,Brenda Lopez Mercado,Damaris Collado,Oscarlett Ampie,Douglas Elizondo,Tatiana Miranda,Fausto A. Bustos Carillo,Juan Carlos Mercado,Krista Latta,Amy Schiller,Bruno Segovia-Chumbez,Sergio R. Ojeda,Nery Sanchez,Miguel Plazaola,Josefina Coloma,M. Elizabeth Halloran,M. Elizabeth Halloran,Lakshmanane Premkumar,Aubree Gordon,Federico Narvaez,Aravinda M. de Silva,Guillermina Kuan,Angel Balmaseda,Eva Harris +25 more
TL;DR: This study investigated prospective pediatric cohorts in Nicaragua that experienced sequential DENV1 to -3, Zika (2004 to 2015), Zika (2016 to 2017), and DENV2 (2018 to 2020) epidemics and found that prior immunity to Zika virus increases the risk of severe dengue disease via cross-reacting antibodies.
Journal ArticleDOI
Infections at the maternal-fetal interface: an overview of pathogenesis and defence.
Christina Megli,Carolyn B. Coyne +1 more
TL;DR: In this article, Megli et al. discuss how TORCH pathogens access the intra-amniotic space and overcome the placental defences that protect against microbial vertical transmission, and provide an overview of how various viral, bacterial and parasitic pathogens traverse the maternal-fetal interface and cause disease.
Journal ArticleDOI
Cross-Reactive Immunity Among Flaviviruses.
TL;DR: The knowledge of the functional immune outcomes that arise from varied flaviviral immune statuses are described and the cross-reactive antibody and T cell immune responses that are protective versus pathological are addressed.
References
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Book
Infectious Diseases of Humans: Dynamics and Control
Roy M. Anderson,Robert M. May +1 more
TL;DR: This book discusses the biology of host-microparasite associations, dynamics of acquired immunity heterogeneity within the human community indirectly transmitted helminths, and the ecology and genetics of hosts and parasites.
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Journal ArticleDOI
Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
Wanwisa Dejnirattisai,Piyada Supasa,Piyada Supasa,Wiyada Wongwiwat,Alexander Rouvinski,Giovanna Barba-Spaeth,Giovanna Barba-Spaeth,Thaneeya Duangchinda,Anavaj Sakuntabhai,Anavaj Sakuntabhai,Van-Mai Cao-Lormeau,Prida Malasit,Prida Malasit,Félix A. Rey,Félix A. Rey,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +17 more
TL;DR: Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZikaV infection, indicating that immunity toDENV might drive greater ZikV replication and have clear implications for disease pathogenesis and future vaccine programs.
Journal ArticleDOI
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus
Lalita Priyamvada,Kendra M. Quicke,William H. Hudson,Nattawat Onlamoon,Jaturong Sewatanon,Srilatha Edupuganti,Kovit Pattanapanyasat,Kulkanya Chokephaibulkit,Mark J. Mulligan,Patrick C. Wilson,Rafi Ahmed,Mehul S. Suthar,Jens Wrammert +12 more
TL;DR: It is shown that both acute and convalescent dengue sera potently bind and neutralize ZIKV and that this cross-reactivity is also evident at the monoclonal level, suggesting that preexisting immunity to DENV may impact protective immune responses against ZikV.
Journal ArticleDOI
Structural basis of potent Zika–dengue virus antibody cross-neutralization
Giovanna Barba-Spaeth,Wanwisa Dejnirattisai,Alexander Rouvinski,Marie Christine Vaney,Iris Medits,Arvind Sharma,Etienne Simon-Loriere,Anavaj Sakuntabhai,Van-Mai Cao-Lormeau,Ahmed Haouz,Patrick England,Karin Stiasny,Juthathip Mongkolsapaya,Franz X. Heinz,Gavin R. Screaton,Félix A. Rey +15 more
TL;DR: It is reported that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus, providing a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and d Dengue virus infections.
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