S
Seiichiro Ogawa
Researcher at Keio University
Publications - 397
Citations - 4902
Seiichiro Ogawa is an academic researcher from Keio University. The author has contributed to research in topics: Total synthesis & Hydroxymethyl. The author has an hindex of 31, co-authored 370 publications receiving 4730 citations. Previous affiliations of Seiichiro Ogawa include Meisei University.
Papers
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Journal ArticleDOI
Chemical chaperone therapy for brain pathology in GM1-gangliosidosis
Junichiro Matsuda,Osamu Suzuki,Akihiro Oshima,Yoshie Yamamoto,Akira Noguchi,Kazuhiro Takimoto,Masayuki Itoh,Yuji Matsuzaki,Yosuke Yasuda,Seiichiro Ogawa,Yuko Sakata,Eiji Nanba,Katsumi Higaki,Yoshimi Ogawa,Lika Tominaga,Kousaku Ohno,Hiroyuki Iwasaki,Hiroshi Watanabe,Roscoe O. Brady,Yoshiyuki Suzuki +19 more
TL;DR: A galactose derivative synthesized for chemical chaperone therapy of a human neurogenetic disease, β-galactosidosis, resulted in significant enhancement of the enzyme activity in the brain and other tissues and a marked decrease of intracellular substrate storage.
Book ChapterDOI
Chemistry of carba-sugars (pseudo-sugars) and their derivatives.
Tetsuo Suami,Seiichiro Ogawa +1 more
TL;DR: This chapter focuses on the chemistry of carbahexopyranoses and their derivatives, which are carbocyclic analogs of true disaccharides in which one or both of the hexose or pentose residues is(are) replaced with a carbasugar.
Journal ArticleDOI
N-octyl-beta-valienamine up-regulates activity of F213I mutant beta-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease.
Hou Lin,Yuko Sugimoto,Yuki Ohsaki,Haruaki Ninomiya,Akira Oka,Miyako Taniguchi,Hiroyuki Ida,Yoshikatsu Eto,Seiichiro Ogawa,Yuji Matsuzaki,Miwa Sawa,Takehiko Inoue,Katsumi Higaki,Eiji Nanba,Kousaku Ohno,Yoshiyuki Suzuki +15 more
TL;DR: It is suggested that NOV works as a chemical chaperone to accelerate transport and maturation of F213I mutant β-Glu and may suggest a therapeutic value of this compound for GD.
Journal ArticleDOI
Total synthesis of antibiotic hygromycin A
TL;DR: The first total synthesis of the antibiotic (−)-hygromycin A (1) has been achieved by a coupling reaction of the sugar moiety and the cyclitol moiety.
Journal ArticleDOI
Total Synthesis of (+)-Lycoricidine and Its 2-Epimer from d-Glucose
TL;DR: A preliminary biological assay revealed that the stereochemistry at the 2-position of lycoricidine plays an important role in its cytotoxic activity.