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Edward J. Osborne
Researcher at University of Utah
Publications - 25
Citations - 3000
Edward J. Osborne is an academic researcher from University of Utah. The author has contributed to research in topics: Gene & DNA methylation. The author has an hindex of 14, co-authored 22 publications receiving 2532 citations.
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Journal ArticleDOI
The genome of Tetranychus urticae reveals herbivorous pest adaptations
Miodrag Grbic,Miodrag Grbic,Thomas Van Leeuwen,Richard M. Clark,Stephane Rombauts,Pierre Rouzé,Vojislava Grbic,Vojislava Grbic,Edward J. Osborne,Wannes Dermauw,Phuong Cao Thi Ngoc,Félix Ortego,Pedro Hernández-Crespo,Isabel Diaz,Manuel Martinez,Maria Navajas,Élio Sucena,Élio Sucena,Sara Magalhães,Lisa M. Nagy,Ryan M. Pace,Sergej Djuranovic,Guy Smagghe,Masatoshi Iga,Olivier Christiaens,Jan A. Veenstra,John Ewer,Rodrigo Mancilla Villalobos,Jeffrey L. Hutter,Stephen D. Hudson,Marisela Vélez,Marisela Vélez,Soojin V. Yi,Jia Zeng,Andre Pires-daSilva,Fernando Roch,Marc Cazaux,Marie Navarro,Vladimir Zhurov,Gustavo Acevedo,Anica Bjelica,Jeffrey A. Fawcett,Jeffrey A. Fawcett,Eric Bonnet,Eric Bonnet,Cindy Martens,Guy Baele,Lothar Wissler,Aminael Sánchez-Rodríguez,Luc Tirry,Catherine Blais,Kristof Demeestere,Stefan R. Henz,T. Ryan Gregory,Johannes Mathieu,Lou Verdon,Laurent Farinelli,Jeremy Schmutz,Erika Lindquist,René Feyereisen,Yves Van de Peer +60 more
TL;DR: The Tetranychus urticae genome is the smallest known arthropod genome as discussed by the authors, which represents the first complete chelicerate genome for a pest and has been annotated with genes associated with feeding on different hosts.
Journal ArticleDOI
Multiple reference genomes and transcriptomes for Arabidopsis thaliana
Xiangchao Gan,Oliver Stegle,Jonas Behr,Joshua G. Steffen,Philipp Drewe,Katie L. Hildebrand,Rune Lyngsoe,Sebastian J. Schultheiss,Edward J. Osborne,Vipin T. Sreedharan,André Kahles,Regina Bohnert,Géraldine Jean,Paul S. Derwent,Paul J. Kersey,Eric J. Belfield,Nicholas P. Harberd,Eric Kemen,Christopher Toomajian,Paula X. Kover,Richard M. Clark,Gunnar Rätsch,Richard Mott +22 more
TL;DR: Genetic differences between Arabidopsis thaliana accessions underlie the plant’s extensive phenotypic variation, and until now these have been interpreted largely in the context of the annotated reference accession Col-0.
Journal ArticleDOI
DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation
Manu J. Dubin,Pei Zhang,Dazhe Meng,Marie Stanislas Remigereau,Edward J. Osborne,Francesco Paolo Casale,Philipp Drewe,André Kahles,Géraldine Jean,Bjarni J. Vilhjálmsson,Joanna Jagoda,Selen Irez,Viktor Voronin,Qiang Song,Quan Long,Gunnar Rätsch,Oliver Stegle,Richard M. Clark,Magnus Nordborg +18 more
TL;DR: Investigation of DNA methylation variation in Swedish Arabidopsis thaliana accessions grown at two different temperatures finds that accessions from colder regions had higher levels of GBM for a significant fraction of the genome, and this was associated with increased transcription for the genes affected.
Journal ArticleDOI
Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin synthesis inhibitor in arthropods
Thomas Van Leeuwen,Peter Demaeght,Edward J. Osborne,Wannes Dermauw,Simon Gohlke,Ralf Nauen,Miodrag Grbic,Luc Tirry,Hans Merzendorfer,Richard M. Clark +9 more
TL;DR: It is shown that the acaricide etoxazole inhibits chitin biogenesis in Tetranychus urticae (the two-spotted spider mite), an economically important pest, and a genetic mapping approach based on high-throughput genome sequencing is developed, which should be powerful for high-resolution mapping of simple traits (resistance or otherwise) in arthropods.
Journal ArticleDOI
A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae
Wannes Dermauw,Edward J. Osborne,Richard M. Clark,Miodrag Grbic,Miodrag Grbic,Luc Tirry,Thomas Van Leeuwen +6 more
TL;DR: The first comprehensive analysis of ABC genes in a polyphagous arthropod herbivore is presented, demonstrating that the broad plant host range and high levels of pesticide resistance in T. urticae are associated with lineage-specific expansions ofABC genes, many of which respond transcriptionally to xenobiotic exposure.