S
Setu M. Vora
Researcher at Boston Children's Hospital
Publications - 16
Citations - 934
Setu M. Vora is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 7, co-authored 13 publications receiving 163 citations. Previous affiliations of Setu M. Vora include University of Iowa & Harvard University.
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Journal ArticleDOI
Gasdermin D pore structure reveals preferential release of mature interleukin-1
Shiyu Xia,Shiyu Xia,Zhibin Zhang,Zhibin Zhang,Venkat Giri Magupalli,Venkat Giri Magupalli,Juan Pablo,Juan Pablo,Ying Dong,Ying Dong,Setu M. Vora,Setu M. Vora,Longfei Wang,Longfei Wang,Tian-Min Fu,Matthew P. Jacobson,Anna Greka,Anna Greka,Judy Lieberman,Judy Lieberman,Jianbin Ruan,Jianbin Ruan,Jianbin Ruan,Hao Wu,Hao Wu +24 more
TL;DR: In this article, the pore and prepore structures of gasdermin D (GSDMD) were analyzed for the role of charge in the preferential release of interleukin (IL)-1β and IL-18.
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
Caroline Junqueira,Ângela C. Crespo,Shahin Ranjbar,Luna B de Lacerda,Mercedes Lewandrowski,Jacob Ingber,B. Parry,Sagi Ravid,Sarah Clark,Marie Rose Schrimpf,F. Ho,Caroline L. Beakes,Justin D. Margolin,Nicole M. Russell,Kyle R. Kays,Julie Boucau,Upasana Das Adhikari,Setu M. Vora,Valerie Leger,Lee Gehrke,Lauren A. Henderson,Erin Janssen,Douglas S. Kwon,Chris Sander,Jonathan Abraham,Marcia B. Goldberg,Haoying Wu,Gautam Raju Mehta,S. Bell,Anne E. Goldfeld,Michael R. Fil,Judy Lieberman +31 more
TL;DR: It is suggested that antibody-mediated SARS-CoV-2 uptake by monocytes/macrophages triggers inflammatory cell death that aborts production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis.
Journal ArticleDOI
Inflammasome activation at the crux of severe COVID-19.
TL;DR: In this article, the authors review evidence that SARS-CoV-2 directly or indirectly activates inflammasomes, which are large multiprotein assemblies that are broadly responsive to pathogen-associated and stress-associated cellular insults, leading to secretion of the pleiotropic IL-1 family cytokines (IL-1β and IL-18), and pyroptosis, an inflammatory form of cell death.
Posted ContentDOI
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release
Caroline Junqueira,Caroline Junqueira,Caroline Junqueira,Ângela C. Crespo,Ângela C. Crespo,Shahin Ranjbar,Shahin Ranjbar,Jacob Ingber,Jacob Ingber,Blair A. Parry,Sagi Ravid,Sagi Ravid,Luna B de Lacerda,Luna B de Lacerda,Luna B de Lacerda,Mercedes Lewandrowski,Mercedes Lewandrowski,Sarah Clark,Felicia Ho,Felicia Ho,Setu M. Vora,Setu M. Vora,Valerie Leger,Caroline Beakes,Justin D. Margolin,Nicole Russell,Lee Gehrke,Lee Gehrke,Upasana Das Adhikari,Lauren A. Henderson,Lauren A. Henderson,Erin Janssen,Erin Janssen,Douglas S. Kwon,Chris Sander,Jonathan Abraham,Michael R. Filbin,Marcia B. Goldberg,Hao Wu,Hao Wu,Gautam Mehta,Gautam Mehta,Steven Bell,Anne E. Goldfeld,Anne E. Goldfeld,Judy Lieberman,Judy Lieberman +46 more
TL;DR: In this paper, the authors showed that ~10% of blood monocytes in COVID-19 patients are dying and infected with SARS-CoV-2, and that expression quantitative trait loci (eQTLs) linked to higher gasdermin D (GSDMD) expression increase the risk of severe CoV-19 disease.
Journal ArticleDOI
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.
Chen Shen,Chen Shen,Runzhi Li,Roberto Negro,Roberto Negro,Jiewei Cheng,Setu M. Vora,Setu M. Vora,Tian-Min Fu,Anmin Wang,Kaixin He,Liudmila Andreeva,Liudmila Andreeva,Pu Gao,Zhigang Tian,Richard A. Flavell,Richard A. Flavell,Shu Zhu,Hao Wu,Hao Wu +19 more
TL;DR: In this article, the liquid-liquid phase separation (LLPS) response of NLRP6 to double-stranded RNA (dsRNA) was shown to be a common response to ligand stimulation.