S
Shelagh Wilson
Researcher at GlaxoSmithKline
Publications - 56
Citations - 16679
Shelagh Wilson is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 39, co-authored 56 publications receiving 15780 citations. Previous affiliations of Shelagh Wilson include University of Texas System & Research Triangle Park.
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Journal ArticleDOI
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Takeshi Sakurai,Akira Amemiya,Makoto Ishii,Ichiyo Matsuzaki,Richard M. Chemelli,Hirokazu Tanaka,S. Clay Williams,James A. Richardson,Gerald P. Kozlowski,Shelagh Wilson,Jonathan R.S. Arch,Robin E. Buckingham,Andrea C. Haynes,Steven A. Carr,Roland S. Annan,Dean E. McNulty,Wu Schyong Liu,Jonathan A. Terrett,Nabil Elshourbagy,Derk J. Bergsma,Masashi Yanagisawa +20 more
TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.
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The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Andrew J. Brown,Susan M. Goldsworthy,Ashley A. Barnes,Michelle M. Eilert,Lili Tcheang,Dion A. Daniels,Alison I. Muir,Mark J. Wigglesworth,Ian Kinghorn,Neil J. Fraser,Nicholas B. Pike,Jay C. Strum,Klaudia Steplewski,Paul R. Murdock,Julie C. Holder,Fiona H. Marshall,Philip G. Szekeres,Shelagh Wilson,Diane M. Ignar,Steve M. Foord,Alan Wise,Simon J. Dowell +21 more
TL;DR: GPR41 was expressed primarily in adipose tissue, whereas the highest levels of GPR43 were found in immune cells, and was activated by similar ligands but with differing specificity for carbon chain length, with pentanoate being the most potent agonist.
Journal ArticleDOI
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids
Celia P. Briscoe,Mohammad Tadayyon,E. John L. Andrews,William G. Benson,Jon K. Chambers,Michelle M. Eilert,Catherine E. Ellis,Nabil Elshourbagy,Aaron S. Goetz,Dana T. Minnick,Paul R. Murdock,Howard Ray Sauls,Usman Shabon,Lisa D. Spinage,Jay C. Strum,Philip G. Szekeres,Kong B. Tan,James M. Way,Diane M. Ignar,Shelagh Wilson,Alison I. Muir +20 more
TL;DR: expression analysis by quantitative reverse transcription-PCR showed that GPR40 was specifically expressed in brain and Pancreas, with expression in rodent pancreas being localized to insulin-producing β-cells.
Journal ArticleDOI
AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1
Alison I. Muir,Larissa Chamberlain,Nabil Elshourbagy,David Michalovich,Darren J. Moore,Amy Calamari,Philip G. Szekeres,Henry M. Sarau,Jon K. Chambers,Paul R. Murdock,Klaudia Steplewski,Usman Shabon,Jane E. Miller,Susan E. Middleton,John G. Darker,Christopher Larminie,Shelagh Wilson,Derk J. Bergsma,Piers C. Emson,Richard L.M. Faull,Karen L. Philpott,David C. Harrison +21 more
TL;DR: High potency agonism was evident from peptides derived from the gene KiSS-1, the expression of which prevents metastasis in melanoma cells, and the nature of the putative cognate ligand for AXOR12 are discussed.
Journal ArticleDOI
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Robert S. Ames,Henry M. Sarau,Johathan K. Chambers,Robert N. Willette,Nambi Aiyar,Anne M. Romanic,Calvert Louden,James J. Foley,Charles F. Sauermelch,Robert W. Coatney,Zhaohui Ao,Jyoti Disa,Stephen Dudley Holmes,Jeffrey M. Stadel,John D. Martin,Wu-Schyong Liu,George I. Glover,Shelagh Wilson,Dean E. McNulty,Catherine E. Ellis,Nabil Elshourbagy,Usman Shabon,John J. Trill,Douglas W. P. Hay,Eliot H. Ohlstein,Derk J. Bergsma,Stephen A. Douglas +26 more
TL;DR: The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far.