S
Shoko Hososhima
Researcher at Nagoya Institute of Technology
Publications - 18
Citations - 514
Shoko Hososhima is an academic researcher from Nagoya Institute of Technology. The author has contributed to research in topics: Channelrhodopsin & Optogenetics. The author has an hindex of 7, co-authored 14 publications receiving 354 citations. Previous affiliations of Shoko Hososhima include Tohoku University.
Papers
More filters
Journal ArticleDOI
Structural basis for Na + transport mechanism by a light-driven Na + pump
Hideaki E. Kato,Keiichi Inoue,Rei Abe-Yoshizumi,Yoshitaka Kato,Hikaru Ono,Masae Konno,Shoko Hososhima,Toru Ishizuka,Mohammad Razuanul Hoque,Hirofumi Kunitomo,Jumpei Ito,Susumu Yoshizawa,Keitaro Yamashita,Mizuki Takemoto,Tomohiro Nishizawa,Reiya Taniguchi,Kazuhiro Kogure,Andrés D. Maturana,Yuichi Iino,Hiromu Yawo,Ryuichiro Ishitani,Hideki Kandori,Osamu Nureki +22 more
TL;DR: Crystal structures of KR2 under neutral and acidic conditions are presented, which represent the resting and M-like intermediate states, respectively, and reveal the molecular basis for light-driven non-proton cation pumps and provide a framework that may advance the development of next-generation optogenetics.
Journal ArticleDOI
Near-infrared (NIR) up-conversion optogenetics
Shoko Hososhima,Hideya Yuasa,Toru Ishizuka,Mohammad Razuanul Hoque,Takayuki Yamashita,Akihiro Yamanaka,Eriko Sugano,Hiroshi Tomita,Hiroshi Tomita,Hiromu Yawo +9 more
TL;DR: A new type of optogenetic system which consists of the donor LNPs and the acceptor ChRs is created, which induced the photo-reactive responses in the near-by cells that expressed ChRs and there remains room for large improvements in the energy efficiency.
Journal ArticleDOI
Crystal structure of heliorhodopsin.
Wataru Shihoya,Keiichi Inoue,Manish Singh,Masae Konno,Shoko Hososhima,Keitaro Yamashita,Kento Ikeda,Akimitsu Higuchi,Tamaki Izume,Sae Okazaki,Masanori Hashimoto,Ritsu Mizutori,Sahoko Tomida,Yumeka Yamauchi,Rei Abe-Yoshizumi,Kota Katayama,Satoshi P. Tsunoda,Satoshi P. Tsunoda,Mikihiro Shibata,Yuji Furutani,Yuji Furutani,Yuji Furutani,Alina Pushkarev,Oded Béjà,Takayuki Uchihashi,Takayuki Uchihashi,Hideki Kandori,Osamu Nureki +27 more
TL;DR: The 2.4-Å-resolution structure of HeR from an uncultured Thermoplasmatales archaeon SG8-52-1 shows that it adopts a similar fold to that of type I rhodopsin—despite the low sequence identity—but there are also several marked differences that provide insights into heliorhodopin function.
Journal ArticleDOI
Schizorhodopsins: A family of rhodopsins from Asgard archaea that function as light-driven inward H+ pumps.
Keiichi Inoue,Satoshi P. Tsunoda,Satoshi P. Tsunoda,Manish Singh,Sahoko Tomida,Shoko Hososhima,Masae Konno,Ryoko Nakamura,Hiroki Watanabe,Paul-Adrian Bulzu,Horia L. Banciu,Adrian-Ştefan Andrei,Takayuki Uchihashi,Rohit Ghai,Oded Béjà,Hideki Kandori +15 more
TL;DR: The function, trimeric structure, and H+ transport mechanism of SzR are similar to that of xenorhodopsin (XeR), a light-driven inward H+ pumping microbial rhodopsins, implying that they evolved convergently.
Journal ArticleDOI
Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.
TL;DR: It is proposed that these bi-stable ChRs would be most suitable for enhancing the intrinsic activity of excitatory pyramidal neurons at a minimal magnitude of irradiance.