Manish Singh

TL;DR: A previously unknown and diverse group of light-sensing rhodopsins that are widespread among a diverse range of microorganisms are identified using functional metagenomics and that are distantly related to type-1 rhodopins.

TL;DR: It is noticed that DOX-Gel nanocarriers are especially effective when injected during the early stage of tumor progression, and achieve a substantial decrease in tumor load in the long term.

TL;DR: Several 2-aryl-5-substituted-2,5-bisbenzimidazole derivatives were synthesized and ability of these derivatives to induce DNA cleavage in the presence of topoisomerase I was evaluated in vitro.

TL;DR: High-speed atomic force microscopy is used to directly observe the oligomeric states in the lipid membrane of various microbial rhodopsins found within eubacteria to archaea, demonstrating that the stoichiometry of the fundamental oligomer of microbial r Rhodopsins strongly correlate with the phylogenetic tree.

TL;DR: The 2.4-Å-resolution structure of HeR from an uncultured Thermoplasmatales archaeon SG8-52-1 shows that it adopts a similar fold to that of type I rhodopsin—despite the low sequence identity—but there are also several marked differences that provide insights into heliorhodopin function.