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Shuai Gao
Researcher at China Agricultural University
Publications - 16
Citations - 282
Shuai Gao is an academic researcher from China Agricultural University. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 7, co-authored 14 publications receiving 224 citations. Previous affiliations of Shuai Gao include Tongji University & Shenzhen University.
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Journal ArticleDOI
Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization.
Kun Tan,Lei An,Kai Miao,Likun Ren,Zhuocheng Hou,Li Tao,Zhenni Zhang,Xiaodong Wang,Wei Xia,Jing-Hao Liu,Zhuqing Wang,Guangyin Xi,Shuai Gao,Linlin Sui,De-Sheng Zhu,Shumin Wang,Zhonghong Wu,Ingolf Bach,Dong-bao Chen,Jianhui Tian +19 more
TL;DR: The data show that iXCI is one of the major epigenetic barriers for the developmental competence of female embryos during preimplantation stage, and targeting erroneous epigenetic modifications may provide a potential approach for preventing IVF-associated complications.
Journal ArticleDOI
High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells
Gang Chang,Shuai Gao,Xinfeng Hou,Zijian Xu,Yanfeng Liu,Lan Kang,Yu Tao,Wenqiang Liu,Bo Huang,Xiaochen Kou,Jiayu Chen,Lei An,Kai Miao,Keqian Di,Zhilong Wang,Kun Tan,Tao Cheng,Tao Cai,Shaorong Gao,Jianhui Tian +19 more
TL;DR: It was found that methylation of an imprinted gene, Zrsr1, was consistently disrupted in the iPSC lines with reduced pluripotency and could not be rescued by improving culture conditions or subcloning of iPSCs.
Journal ArticleDOI
The combination of Tet1 with Oct4 generates high-quality mouse-induced pluripotent stem cells.
Jiayu Chen,Yawei Gao,Hua Huang,Kai Xu,Xia Chen,Yonghua Jiang,Hui Li,Shuai Gao,Yu Tao,Hong Wang,Yong Zhang,Hailin Wang,Tao Cai,Shaorong Gao +13 more
TL;DR: Evidence is provided that Tet1 (T) can replace multiple transcription factors during somatic cell reprogramming and can generate high‐quality mouse induced pluripotent stem cells (iPSCs) with Oct4 (O).
Journal ArticleDOI
Generation and characterization of stable pig pregastrulation epiblast stem cell lines.
Minglei Zhi,Jinying Zhang,Qianzi Tang,Dawei Yu,Shuai Gao,Dengfeng Gao,Pengliang Liu,Jianxiong Guo,Tang Hai,Jie Gao,Suying Cao,Zimo Zhao,Chongyang Li,Xiaogang Weng,Mengnan He,Tianzhi Chen,Yingjie Wang,Keren Long,Deling Jiao,Guanglei Li,Jiaman Zhang,Yan Liu,Yu Lin,Daxin Pang,Qianqian Zhu,Naixin Chen,Jingjing Huang,Xinze Chen,Yixuan Yao,Jingcang Yang,Zicong Xie,Xianya Huang,Mengxin Liu,Ran Zhang,Qiuyan Li,Yiliang Miao,Jianhui Tian,Xingxu Huang,Hongsheng Ouyang,Bofeng Liu,Wei Xie,Qi Zhou,Hong-Jiang Wei,Zhonghua Liu,Caihong Zheng,Mingzhou Li,Jianyong Han +46 more
TL;DR: In this article, a large-scale single-cell transcriptome analysis of pig embryos from embryonic day (E) 0 to E14, specifically, the tracing of pluripotency changes during epiblast development, was performed.
Journal ArticleDOI
Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells
Shuai Gao,Caihong Zheng,Gang Chang,Wenqiang Liu,Xiaochen Kou,Kun Tan,Li Tao,Kai Xu,Hong Wang,Jun Cai,Jianhui Tian,Shaorong Gao +11 more
TL;DR: It is demonstrated that all-iPSC mice generated through tetraploid blastocysts complementation can tolerate the accumulation of somatic mutations for up to six generations using a Tet-on inducible reprogramming system, and that pluripotent stem cells are heterogeneous in terms of possessing a set of copy-number alterations (CNAs).