S
Silvain Pinaud
Researcher at IFREMER
Publications - 22
Citations - 644
Silvain Pinaud is an academic researcher from IFREMER. The author has contributed to research in topics: Innate immune system & Biomphalaria glabrata. The author has an hindex of 10, co-authored 20 publications receiving 406 citations. Previous affiliations of Silvain Pinaud include University of Perpignan & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Innate immune memory: An evolutionary perspective.
Benjamin Gourbal,Silvain Pinaud,Gerold J. M. Beckers,Jos W. M. van der Meer,Uwe Conrath,Mihai G. Netea,Mihai G. Netea +6 more
TL;DR: It is emphasized that innate immune responses have the capacity to be “primed” or “trained”, thereby exerting a yet unknown type of immunological memory upon re‐infection.
Journal ArticleDOI
A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata
Silvain Pinaud,Julien Portela,David Duval,Fanny Nowacki,Fanny Nowacki,Marie-Aude Olive,Jean-François Allienne,Richard Galinier,Nolwenn M. Dheilly,Nolwenn M. Dheilly,Sylvie Kieffer-Jaquinod,Guillaume Mitta,André Théron,Benjamin Gourbal +13 more
TL;DR: The first evidence that a shift from a cellular immune response to a humoral immune response occurs during the development of innate memory is provided, in the Lophotrochozoan snail, Biomphalaria glabrata.
Journal ArticleDOI
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung
Martijn J. Schuijs,Shaun Png,Arianne C. Richard,Anastasia Tsyben,Anastasia Tsyben,Gregory Hamm,Julie Stockis,Celine Garcia,Silvain Pinaud,Ashley Nicholls,Xavier Romero Ros,Jing Su,Matthew D. Eldridge,Angela Riedel,Eva M. Serrao,Hans-Reimer Rodewald,Matthias Mack,Jacqueline D. Shields,E. Suzanne Cohen,Andrew N. J. McKenzie,Richard J. A. Goodwin,Richard J. A. Goodwin,Kevin M. Brindle,John C. Marioni,John C. Marioni,John C. Marioni,Timotheus Y.F. Halim +26 more
TL;DR: Using multiple models of lung metastasis, it is shown that interleukin (IL)-33-dependent ILC2 activation in the lung is involved centrally in promoting tumor burden and an important function of IL-33 and I LC2s is revealed via their capacity to suppress innate type 1 immunity.
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A microsporidian impairs Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes
Jeremy K. Herren,Jeremy K. Herren,Lilian Mbaisi,Lilian Mbaisi,Enock Mararo,Edward Edmond Makhulu,Victor A. Mobegi,Hellen Butungi,Hellen Butungi,Maria Vittoria Mancini,Joseph Wang’ang’a Oundo,Evan Teal,Silvain Pinaud,Mara K. N. Lawniczak,Jordan Jabara,Godfrey Nattoh,Godfrey Nattoh,Steven P. Sinkins +17 more
TL;DR: A vertically transmitted microsporidian symbiont (Microsporidia MB) in the An.
Journal ArticleDOI
Specific Pathogen Recognition by Multiple Innate Immune Sensors in an Invertebrate
TL;DR: A fast interactome approach was developed, usable on any host–pathogen couple, to identify soluble proteins capable of directly or indirectly detecting the presence of pathogens and revealed that extracellular actin present in snail hemolymph was able to bind to yeasts and induce their clotting, a preliminary step for their elimination by the snail immune system.