S
Simon Gordonov
Researcher at Massachusetts Institute of Technology
Publications - 19
Citations - 2572
Simon Gordonov is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Receptor tyrosine kinase & Cancer. The author has an hindex of 12, co-authored 19 publications receiving 2238 citations. Previous affiliations of Simon Gordonov include Rutgers University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
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Cytoskeleton-based forecasting of stem cell lineage fates
Matthew D. Treiser,Eric Yang,Simon Gordonov,Daniel M. Cohen,Ioannis P. Androulakis,Joachim Kohn,Christopher S. Chen,Prabhas V. Moghe +7 more
TL;DR: This study reports that higher-order variations in cell shape and cytoskeletal organization that occur within hours of stimulation forecast the lineage commitment fates of human mesenchymal stem cells (hMSCs).
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Expression2Kinases: mRNA Profiling Linked to Multiple Upstream Regulatory Layers
TL;DR: The X2K approach can advance the understanding of cell signaling and unravel drugs mechanisms of action by integrating chromatin immuno-precipitation data, protein-protein interactions and kinase-substrate phosphorylation reactions, and can better identify regulatory mechanisms upstream of genome-wide differences in gene expression.
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Skeletal stem cell physiology on functionally distinct titania nanotopographies
Laura E. McNamara,Terje Sjöström,Karl Burgess,Joseph J. Kim,Er Liu,Simon Gordonov,Prabhas V. Moghe,R. M. Dominic Meek,Richard O.C. Oreffo,Bo Su,Matthew J. Dalby +10 more
TL;DR: Metabolomics was used as a novel means of assessing cellular responses to the biomaterial substrates by analysing the global metabolite profile of the cells on the substrata and shows promise as a technique with high data yield for evaluating cell interactions with materials of different surface chemistry or topography.
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Synthesis and Cytotoxicity of Y(2)O(3) Nanoparticles of Various Morphologies.
TL;DR: The synthesis, characterization, and cytotoxicity of nanoparticles of different morphologies of yttrium oxide, a promising material for biological imaging applications, are reported, demonstrating the importance of nanoparticle chemistry on in vitro cytot toxicity.