S
Slava S. Epstein
Researcher at Northeastern University
Publications - 118
Citations - 10308
Slava S. Epstein is an academic researcher from Northeastern University. The author has contributed to research in topics: Species richness & Population. The author has an hindex of 42, co-authored 117 publications receiving 9270 citations. Previous affiliations of Slava S. Epstein include Boston Children's Hospital & Ningbo University.
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Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
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Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment.
TL;DR: A diffusion chamber was designed that allowed the growth of previously uncultivated microorganisms in a simulated natural environment and isolated representative marine organisms, which formed colonies in the presence of other microorganisms.
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Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species
Dominica Nichols,N. Cahoon,E. M. Trakhtenberg,Ly Pham,A. Mehta,A. Belanger,T. Kanigan,Kim Lewis,Slava S. Epstein +8 more
TL;DR: It is shown that microbial recovery in the ichip exceeds manyfold that afforded by standard cultivation, and the grown species are of significant phylogenetic novelty.
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Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria
Anthony D'Onofrio,Jason M. Crawford,Eric J. Stewart,Kathrin Witt,Ekaterina Gavrish,Slava S. Epstein,Jon Clardy,Kim Lewis +7 more
TL;DR: It is shown here that previously uncultured isolates from marine sediment biofilm grow on a Petri dish in the presence of cultured organisms from the same environment.
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Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
Ekaterina Gavrish,Clarissa S. Sit,Shugeng Cao,Olga Kandror,Amy Spoering,Aaron J. Peoples,Losee Lucy Ling,Ashley Fetterman,Dallas Hughes,Anthony Bissell,Heather Torrey,Tatos Akopian,Andreas Mueller,Slava S. Epstein,Alfred L. Goldberg,Jon Clardy,Kim Lewis +16 more
TL;DR: It is shown that lassomycin binds to a highly acidic region of the ClpC1 ATPase complex and markedly stimulates its ATPase activity without stimulating ClpP1P2-catalyzed protein breakdown, which is essential for viability of mycobacteria.