S
Solrun J. Steine
Researcher at University of Bergen
Publications - 28
Citations - 887
Solrun J. Steine is an academic researcher from University of Bergen. The author has contributed to research in topics: Gene & KRAS. The author has an hindex of 11, co-authored 24 publications receiving 793 citations. Previous affiliations of Solrun J. Steine include Haukeland University Hospital.
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Journal ArticleDOI
Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: Frequent PIK3CA amplification and AKT phosphorylation
TL;DR: An increased activation state of AKT kinase appears to be present in cervical carcinogenesis, and may be accounted for by PIK3CA amplification, whereas PTEN mutation seems to be of little importance.
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A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis
Karianne Fjeld,Frank Ulrich Weiss,Denise Lasher,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Bente B. Johansson,Bente B. Johansson,Holger Kirsten,Claudia Ruffert,Emmanuelle Masson,Solrun J. Steine,Peter Bugert,Miriam Cnop,Robert Grützmann,Julia Mayerle,Joachim Mössner,Monika Ringdal,Monika Ringdal,Hans-Ulrich Schulz,Matthias Sendler,Peter Simon,Paweł Sztromwasser,Paweł Sztromwasser,Janniche Torsvik,Janniche Torsvik,Markus Scholz,Erling Tjora,Erling Tjora,Claude Férec,Heiko Witt,Markus M. Lerch,Pål R. Njølstad,Pål R. Njølstad,Stefan Johansson,Stefan Johansson,Anders Molven,Anders Molven +37 more
TL;DR: A hybrid allele (CEL-HYB) originating from a crossover between CEL and its neighboring pseudogene, CELP is described, implicate a new pathway distinct from the protease-antiprotease system of pancreatic acinar cells in chronic pancreatitis.
Journal ArticleDOI
Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants
Hanne E. Puntervoll,Xiaohong R. Yang,Hildegunn Hoøberg Vetti,Ingeborg M. Bachmann,Ingeborg M. Bachmann,Marie-Françoise Avril,M. Benfodda,Caterina Catricalà,Stéphane Dalle,Anne Benedicte Duval-Modeste,Paola Ghiorzo,Paola Grammatico,Mark Harland,Nicholas K. Hayward,Hui Han Hu,Thomas Jouary,Tanguy Martin-Denavit,Aija Ozola,Jane M. Palmer,Lorenza Pastorino,Dace Pjanova,Nadem Soufir,Solrun J. Steine,Alexander J. Stratigos,Luc Thomas,Julie Tinat,Hensin Tsao,Ruta Veinalde,Margaret A. Tucker,Brigitte Bressac-de Paillerets,Julia Newton-Bishop,Alisa M. Goldstein,Lars A. Akslen,Lars A. Akslen,Anders Molven,Anders Molven +35 more
TL;DR: This study shows that families with CDK4 germline mutations cannot be distinguished phenotypically from CDKN2A melanoma families, which are characterised by early onset of disease, increased occurrence of clinically atypical nevi, and development of MPM.
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A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation
Anders Molven,Magne B. Grimstvedt,Solrun J. Steine,Mark Harland,Marie-Françoise Avril,Nicholas K. Hayward,Lars A. Akslen +6 more
TL;DR: It is reported that CDK4 codon 24 is mutated from CGT to CAT (Arg24His) in this unusually large melanoma kindred, suggesting an etiology different from that of the skin tumors.
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Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes
TL;DR: It is concluded that the BRAF and EGFR mutations commonly seen in a variety of human cancers are generally absent from pancreatic ductal adenocarcinomas, apparently because these tumors depend on no more than one genetic hit in the EGFR-RAS-RAF signaling pathway.