C
Claudia Ruffert
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 22
Citations - 699
Claudia Ruffert is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Pancreatitis & Gene. The author has an hindex of 10, co-authored 22 publications receiving 559 citations. Previous affiliations of Claudia Ruffert include Leipzig University.
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Journal ArticleDOI
CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?
Jonas Rosendahl,Jonas Rosendahl,Olfert Landt,Jana Bernadova,Peter Kovacs,Niels Teich,Hans Bödeker,Volker Keim,Claudia Ruffert,Joachim Mössner,Andreas Kage,Michael Stumvoll,David A. Groneberg,Renate Krüger,W Luck,Matthias Treiber,Michael Becker,Heiko Witt,Heiko Witt +18 more
TL;DR: The study demonstrates the complexity of genetic interactions in CP and a minor influence of CFTR alterations in CP development and accumulated CFTR variants are less pronounced than reported previously.
Journal ArticleDOI
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis
Karianne Fjeld,Frank Ulrich Weiss,Denise Lasher,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Bente B. Johansson,Bente B. Johansson,Holger Kirsten,Claudia Ruffert,Emmanuelle Masson,Solrun J. Steine,Peter Bugert,Miriam Cnop,Robert Grützmann,Julia Mayerle,Joachim Mössner,Monika Ringdal,Monika Ringdal,Hans-Ulrich Schulz,Matthias Sendler,Peter Simon,Paweł Sztromwasser,Paweł Sztromwasser,Janniche Torsvik,Janniche Torsvik,Markus Scholz,Erling Tjora,Erling Tjora,Claude Férec,Heiko Witt,Markus M. Lerch,Pål R. Njølstad,Pål R. Njølstad,Stefan Johansson,Stefan Johansson,Anders Molven,Anders Molven +37 more
TL;DR: A hybrid allele (CEL-HYB) originating from a crossover between CEL and its neighboring pseudogene, CELP is described, implicate a new pathway distinct from the protease-antiprotease system of pancreatic acinar cells in chronic pancreatitis.
Journal ArticleDOI
Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study
Monique Derikx,Peter Kovacs,Markus Scholz,Emmanuelle Masson,Jian-Min Chen,Claudia Ruffert,Peter Lichtner,Rene H. M. te Morsche,Giulia Martina Cavestro,Claude Férec,Joost P H Drenth,Heiko Witt,Jonas Rosendahl +12 more
TL;DR: The single-nucleotide polymorphisms rs10273639 at the PRSS1–PRSS2 locus and rs7057398 and rs12688220 at the CLDN2–MORC4 locus are associated with CP and strongly associate with ACP, but only rs70 57398 with NACP in female patients.
Journal ArticleDOI
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
Jonas Rosendahl,Holger Kirsten,Eszter Hegyi,Peter Kovacs,Frank Ulrich Weiss,Helmut Laumen,Peter Lichtner,Claudia Ruffert,Jian-Min Chen,Emmanuelle Masson,Sebastian Beer,Constantin Zimmer,Katharina Seltsam,Hana Algül,Florence Bühler,Marco J. Bruno,Peter Bugert,Ralph Burkhardt,Giulia Martina Cavestro,Halina Cichoż-Lach,Antoni Farré,Josef Frank,Giovanni Gambaro,Sebastian Gimpfl,Harald Grallert,Heidi Griesmann,Robert Grützmann,Claus Hellerbrand,Péter Hegyi,Marcus Hollenbach,Sevastitia Iordache,Grazyna Jurkowska,Volker Keim,Falk Kiefer,Sebastian Krug,Olfert Landt,Milena Di Leo,Markus M. Lerch,Philippe Lévy,Markus Löffler,Matthias Löhr,Maren Ludwig,Milan Macek,Núria Malats,Ewa Małecka-Panas,Giovanni Malerba,Karl Mann,Julia Mayerle,Sonja Mohr,Rene H. M. te Morsche,Marie Motyka,Sebastian Mueller,Thomas Müller,Markus M. Nöthen,Sergio Pedrazzoli,Stephen P. Pereira,Annette Peters,Roland H. Pfützer,Francisco X. Real,Vinciane Rebours,Monika Ridinger,Marcella Rietschel,Eva Rösmann,Adrian Saftoiu,Alexander Schneider,Hans-Ulrich Schulz,Nicole Soranzo,Nicole Soranzo,Michael Soyka,Peter Simon,James R. A. Skipworth,Felix Stickel,Konstantin Strauch,Michael Stumvoll,Pier Alberto Testoni,Anke Tönjes,Lena Werner,Jens Werner,Norbert Wodarz,Martin Ziegler,Atsushi Masamune,Joachim Mössner,Claude Férec,Patrick Michl,Joost P.H. Drenth,Heiko Witt,Markus Scholz,Miklós Sahin-Tóth +87 more
TL;DR: An inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
Journal ArticleDOI
Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis
Denise Lasher,András Szabó,András Szabó,Atsushi Masamune,Jian-Min Chen,Xunjun Xiao,David C. Whitcomb,M. Michael Barmada,Maren Ewers,Claudia Ruffert,Sumit Paliwal,Prachand Issarapu,Seema Bhaskar,K. Radha Mani,Giriraj R. Chandak,Helmut Laumen,Emmanuelle Masson,Kiyoshi Kume,Shin Hamada,Eriko Nakano,Katharina Seltsam,Peter Bugert,Thomas Müller,David A. Groneberg,Tooru Shimosegawa,Jonas Rosendahl,Jonas Rosendahl,Claude Férec,Mark E. Lowe,Heiko Witt,Miklós Sahin-Tóth +30 more
TL;DR: It is indicated that protease-sensitive PNLIP variants are novel genetic risk factors for the development of CP.